{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie J"],"funding":["National Natural Science Foundation of China"],"pagination":["3487-3496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11489259"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(11)"],"pubmed_abstract":["<h4>Objective</h4>Association between mitochondrial dysfunction and osteoarthritis (OA) has been consistently investigated, yet their genetic association remains obscure. In this study, mitochondrial-related genes were used as instrumental variables to proxy for mitochondrial dysfunction, and summary data of knee OA (KOA) were used as outcome to examine their genetic association.<h4>Methods</h4>We obtained 1136 mitochondrial-related genes from the human MitoCarta3.0 database. Genetic proxy instruments for mitochondrial-related genes from studies of corresponding gene expression (n = 31,684) and protein (n = 35,559) quantitative trait locus (eQTLs and pQTLs), respectively. Aggregated data for KOA (62,497 KOA cases and 333,557 controls) were extracted from the largest OA genome-wide associat"],"journal":["Clinical rheumatology"],"pubmed_title":["Identification of genetic association between mitochondrial dysfunction and knee osteoarthritis through integrating multi-omics: a summary data-based Mendelian randomization study."],"pmcid":["PMC11489259"],"funding_grant_id":["No.82072432"],"pubmed_authors":["Xu K","Ma R","Guo J","Xu P","Xie J","Yang M","Wan X","Xu X","Yu H"],"additional_accession":[]},"is_claimable":false,"name":"Identification of genetic association between mitochondrial dysfunction and knee osteoarthritis through integrating multi-omics: a summary data-based Mendelian randomization study.","description":"<h4>Objective</h4>Association between mitochondrial dysfunction and osteoarthritis (OA) has been consistently investigated, yet their genetic association remains obscure. In this study, mitochondrial-related genes were used as instrumental variables to proxy for mitochondrial dysfunction, and summary data of knee OA (KOA) were used as outcome to examine their genetic association.<h4>Methods</h4>We obtained 1136 mitochondrial-related genes from the human MitoCarta3.0 database. Genetic proxy instruments for mitochondrial-related genes from studies of corresponding gene expression (n = 31,684) and protein (n = 35,559) quantitative trait locus (eQTLs and pQTLs), respectively. Aggregated data for KOA (62,497 KOA cases and 333,557 controls) were extracted from the largest OA genome-wide associat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-01T07:33:52.587Z","creation":"2025-04-21T21:52:42.692Z"},"accession":"S-EPMC11489259","cross_references":{"pubmed":["39259428"],"doi":["10.1007/s10067-024-07136-7"]}}