{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kung TFC"],"funding":["Canadian Institutes of Health Research","CIHR"],"pagination":["44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11489293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(6)"],"pubmed_abstract":["Intracerebral hemorrhage (ICH) is a stroke subtype with a high mortality rate (~ 40%). After ICH, the mass effect of the hematoma and edema contribute to raised intracranial pressure (ICP) and poor outcome. Endogenous compensatory mechanisms that blunt ICP elevations include redirection of venous blood and cerebrospinal fluid, along with brain tissue compliance (e.g., decreased cell volume, increased cell density); however, these limited reserves can be exhausted after severe stroke, resulting in decompensated ICP that requires careful clinical management. Management strategies can include administration of hypertonic saline (HTS), an osmotic agent that putatively attenuates edema, and thereby ICP elevations. Evidence regarding the efficacy of HTS treatment following ICH remains limited. I"],"journal":["Neurotoxicity research"],"pubmed_title":["No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage."],"pmcid":["PMC11489293"],"funding_grant_id":["174992"],"pubmed_authors":["Kalisvaart ACJ","Jickling GC","Kung TFC","Suerte ACC","Colbourne F","van Landeghem FKH"],"additional_accession":[]},"is_claimable":false,"name":"No Benefit of 3% Hypertonic Saline Following Experimental Intracerebral Hemorrhage.","description":"Intracerebral hemorrhage (ICH) is a stroke subtype with a high mortality rate (~ 40%). After ICH, the mass effect of the hematoma and edema contribute to raised intracranial pressure (ICP) and poor outcome. Endogenous compensatory mechanisms that blunt ICP elevations include redirection of venous blood and cerebrospinal fluid, along with brain tissue compliance (e.g., decreased cell volume, increased cell density); however, these limited reserves can be exhausted after severe stroke, resulting in decompensated ICP that requires careful clinical management. Management strategies can include administration of hypertonic saline (HTS), an osmotic agent that putatively attenuates edema, and thereby ICP elevations. Evidence regarding the efficacy of HTS treatment following ICH remains limited. I","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T09:42:34.898Z","creation":"2025-04-04T09:42:34.898Z"},"accession":"S-EPMC11489293","cross_references":{"pubmed":["39422850"],"doi":["10.1007/s12640-024-00722-2"]}}