{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Facen E"],"funding":["Associazione Italiana per la Ricerca sul Cancro","Ministero dell'Università e della Ricerca","Ministero della Salute","Fondazione Pezcoller","Ministerstvo Školství, Mládeže a Tělovýchovy","Ministero dell’Università e della Ricerca","H2020 Marie Skłodowska-Curie Actions","European Regional Development Fund"],"pagination":["24501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11489580"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The RNA binding protein Human Antigen R (HuR) has been identified as a main regulator of the innate immune response and its inhibition can lead to beneficial anti-inflammatory effects. To this aim, we previously synthesized a novel class of small molecules named Tanshinone Mimics (TMs) able to interfere with HuR-RNA binding, and that dampen the LPS-induced immune response. Herein, we present a novel series of TMs, encompassing thiophene 3/TM9 and 4/TM10, furan 5/TM11 and 6/TM12, pyrrole 7b/TM13, and pyrazole 8. The furan-containing 5(TM11) showed the greatest inhibitory effect of the series on HuR-RNA complex formation, as suggested by RNA Electromobility Shift Assay and Time-Resolved FRET. Molecular Dynamics Calculation of HuR - 5/TM11 interaction, quantum mechanics approaches and Surface"],"journal":["Scientific reports"],"pubmed_title":["Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages."],"pmcid":["PMC11489580"],"funding_grant_id":["GR2019-12369266","LM2023042",". CZ.02.1.01/0.0/0.0/18_046/0015974","813284","21548","PNRR-MUR NextGenerationEU cod. CN00000041"],"pubmed_authors":["Lotti R","Provenzani A","Facen E","Paladino D","Marinelli L","Houser J","Pietra V","Assoni G","Seneci P","Carreira A","Bonomo I","Arosio D","Donati G","Fava LL"],"additional_accession":[]},"is_claimable":false,"name":"Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages.","description":"The RNA binding protein Human Antigen R (HuR) has been identified as a main regulator of the innate immune response and its inhibition can lead to beneficial anti-inflammatory effects. To this aim, we previously synthesized a novel class of small molecules named Tanshinone Mimics (TMs) able to interfere with HuR-RNA binding, and that dampen the LPS-induced immune response. Herein, we present a novel series of TMs, encompassing thiophene 3/TM9 and 4/TM10, furan 5/TM11 and 6/TM12, pyrrole 7b/TM13, and pyrazole 8. The furan-containing 5(TM11) showed the greatest inhibitory effect of the series on HuR-RNA complex formation, as suggested by RNA Electromobility Shift Assay and Time-Resolved FRET. Molecular Dynamics Calculation of HuR - 5/TM11 interaction, quantum mechanics approaches and Surface","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-01T06:37:21.851Z","creation":"2025-04-04T22:47:54.308Z"},"accession":"S-EPMC11489580","cross_references":{"pubmed":["39424621"],"doi":["10.1038/s41598-024-73309-8"]}}