{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Payne T"],"funding":["NIA NIH HHS","NINDS NIH HHS"],"pagination":["100349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11490679"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.<h4>Methods</h4>We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (<i>n</i>=24) and after surgery (<i>n</i>=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.<h4>Results</h4>CS"],"journal":["BJA open"],"pubmed_title":["Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium."],"pmcid":["PMC11490679"],"funding_grant_id":["R01 AG057525","R35 NS097976","RF1 AG064926","R01 AG063849"],"pubmed_authors":["Meyer-Franke A","Lennertz RC","Payne T","Akassoglou K","Kunkel D","Zetterberg H","Taylor J","Sanders RD","Konieczka K","Ingram F","Pearce RA","Blennow K","Terrando N"],"additional_accession":[]},"is_claimable":false,"name":"Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.","description":"<h4>Background</h4>We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.<h4>Methods</h4>We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (<i>n</i>=24) and after surgery (<i>n</i>=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.<h4>Results</h4>CS","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-07-15T05:14:03.68Z","creation":"2025-04-04T02:21:02.685Z"},"accession":"S-EPMC11490679","cross_references":{"pubmed":["39429436"],"doi":["10.1016/j.bjao.2024.100349"]}}