biostudies-literaturePayne TNIA NIH HHSNINDS NIH HHS100349https://www.ebi.ac.uk/biostudies/studies/S-EPMC11490679biostudies-literatureUnknown12<h4>Background</h4>We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.<h4>Methods</h4>We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (<i>n</i>=24) and after surgery (<i>n</i>=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.<h4>Results</h4>CSBJA openAssociation of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.PMC11490679R01 AG057525R35 NS097976RF1 AG064926R01 AG063849Meyer-Franke ALennertz RCPayne TAkassoglou KKunkel DZetterberg HTaylor JSanders RDKonieczka KIngram FPearce RABlennow KTerrando NfalseAssociation of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.<h4>Background</h4>We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.<h4>Methods</h4>We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (<i>n</i>=24) and after surgery (<i>n</i>=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.<h4>Results</h4>CS2024-01-01T00:00:00Z2024 Dec2026-07-15T05:14:03.68Z2025-04-04T02:21:02.685ZS-EPMC114906793942943610.1016/j.bjao.2024.100349