{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Silva R"],"funding":["Fundação para a Ciência e a Tecnologia","LA-REAL","CE3C"],"pagination":["316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11491027"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Submicroscopic Plasmodium infections can be a source of persistent malaria transmission. The aim of this study was to assess their frequency, distribution, morbidity and associated factors in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau, where the Plasmodium falciparum is the predominant Plasmodium species.<h4>Methods</h4>Dried fingerprick whole blood samples from 601 participants in the 2017 national, household-based, cross-sectional survey to estimate malaria prevalence were subjected to DNA extraction. The DNA was used in nested end-point PCR assays targeting genus- and species-specific regions of the Plasmodium 18S rRNA genes. Statistical analysis of socio-demographic, clinical and molecular data was carried out using the Statistical Package"],"journal":["Malaria journal"],"pubmed_title":["Assessing the burden of submicroscopic Plasmodium infections in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau."],"pmcid":["PMC11491027"],"funding_grant_id":["UIBD/00329/2020","GHTM-UID/04413/2020","LA/P/0117/2020"],"pubmed_authors":["Lopes LF","Rodrigues A","Medeiros MM","Silva R","Arez AP"],"additional_accession":[]},"is_claimable":false,"name":"Assessing the burden of submicroscopic Plasmodium infections in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau.","description":"<h4>Background</h4>Submicroscopic Plasmodium infections can be a source of persistent malaria transmission. The aim of this study was to assess their frequency, distribution, morbidity and associated factors in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau, where the Plasmodium falciparum is the predominant Plasmodium species.<h4>Methods</h4>Dried fingerprick whole blood samples from 601 participants in the 2017 national, household-based, cross-sectional survey to estimate malaria prevalence were subjected to DNA extraction. The DNA was used in nested end-point PCR assays targeting genus- and species-specific regions of the Plasmodium 18S rRNA genes. Statistical analysis of socio-demographic, clinical and molecular data was carried out using the Statistical Package","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-18T13:07:33.102Z","creation":"2025-04-06T22:40:00.04Z"},"accession":"S-EPMC11491027","cross_references":{"pubmed":["39427159"],"doi":["10.1186/s12936-024-05138-z"]}}