{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Li J"],"funding":["Heilongjiang University of Chinese Medicine"],"pubmed_abstract":["<h4>Background</h4>T cell receptor (TCR)-T cell therapy is an innovative form of cancer immunotherapy that genetically modifies patients' T cells to target and destroy cancer cells. However, the current status of clinical trials of TCR-T cell therapy for the treatment of cancer remains unclear. This study aimed to comprehensively analyze the registration trials related to TCR-T cell therapy for the treatment of cancer.<h4>Methods</h4>A comprehensive search was conducted in the Trialtrove database for all clinical trials related to TCR-T cell therapy registered by August 1, 2024. Inclusion criteria focused on trials targeting TCR-T cell therapy for oncology, and excluded observational studies and incomplete data. Statistical analysis was performed on key trial characteristics, with between-"],"journal":["Frontiers in immunology"],"pagination":["1487782"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11493697"],"repository":["biostudies-literature"],"pubmed_title":["Clinical advances and challenges associated with TCR-T cell therapy for cancer treatment."],"pmcid":["PMC11493697"],"pubmed_authors":["Fu T","Li J","Xing G","Zhang Y","Tong Y","Li K","Cai H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Clinical advances and challenges associated with TCR-T cell therapy for cancer treatment.","description":"<h4>Background</h4>T cell receptor (TCR)-T cell therapy is an innovative form of cancer immunotherapy that genetically modifies patients' T cells to target and destroy cancer cells. However, the current status of clinical trials of TCR-T cell therapy for the treatment of cancer remains unclear. This study aimed to comprehensively analyze the registration trials related to TCR-T cell therapy for the treatment of cancer.<h4>Methods</h4>A comprehensive search was conducted in the Trialtrove database for all clinical trials related to TCR-T cell therapy registered by August 1, 2024. Inclusion criteria focused on trials targeting TCR-T cell therapy for oncology, and excluded observational studies and incomplete data. Statistical analysis was performed on key trial characteristics, with between-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-05T03:08:59.072Z","creation":"2025-04-06T14:22:58.938Z"},"accession":"S-EPMC11493697","cross_references":{"pubmed":["39439803"],"doi":["10.3389/fimmu.2024.1487782"]}}