biostudies-literatureUnknown16(9)Mansur A<h4>Background</h4>Primary lung signet-ring cell carcinoma (LSRCC) is a rare form of aggressive lung cancer whose clinical features remain inadequately discerned. The objective of this study was to evaluate the clinicopathological characteristics and independent prognostic factors of primary LSRCC.<h4>Methods</h4>Overall survival (OS) of patients with LSRCC, lung adenocarcinoma (LAC), and lung mucinous adenocarcinoma (LMAC) in the National Cancer Database from 2004 to 2018 was evaluated using Kaplan-Meier and multivariable Cox proportional hazards modeling. Independent prognostic indicators for patients with LSRCC were determined using multivariable Cox proportional hazards analysis.<h4>Results</h4>A total of 1,705 LSRCC, 504,006 LAC, and 15,883 LMAC patients were included in our analysis.Journal of thoracic disease5899-5908https://www.ebi.ac.uk/biostudies/studies/S-EPMC11494572biostudies-literaturePrimary lung signet-ring cell carcinoma: a national analysis.PMC11494572Mansur ASaleem ZPotter ALSenthil PYang CJMathey-Andrews CfalsePrimary lung signet-ring cell carcinoma: a national analysis.<h4>Background</h4>Primary lung signet-ring cell carcinoma (LSRCC) is a rare form of aggressive lung cancer whose clinical features remain inadequately discerned. The objective of this study was to evaluate the clinicopathological characteristics and independent prognostic factors of primary LSRCC.<h4>Methods</h4>Overall survival (OS) of patients with LSRCC, lung adenocarcinoma (LAC), and lung mucinous adenocarcinoma (LMAC) in the National Cancer Database from 2004 to 2018 was evaluated using Kaplan-Meier and multivariable Cox proportional hazards modeling. Independent prognostic indicators for patients with LSRCC were determined using multivariable Cox proportional hazards analysis.<h4>Results</h4>A total of 1,705 LSRCC, 504,006 LAC, and 15,883 LMAC patients were included in our analysis.2024-01-01T00:00:00Z2024 Sep2025-04-03T23:51:53.506Z2025-04-03T23:51:53.506ZS-EPMC114945723944487210.21037/jtd-24-102