biostudies-literatureUnknown16(9)Abdelghani R<h4>Background</h4>Electromagnetic navigation bronchoscopy (ENB) and shape-sensing robotic-assisted bronchoscopy (ssRAB) are minimally invasive technologies for the diagnosis of pulmonary nodules. Cone-beam computed tomography (CBCT) has shown to increase diagnostic yield by allowing real-time confirmation of position of lesion and biopsy tool. There is a lack of comparative studies of such platforms using CBCT guidance to overcome computed tomography to body divergence. The aim of this study was to compare the diagnostic yield of ENB- and ssRAB-guided CBCT for biopsy of pulmonary nodules.<h4>Methods</h4>We conducted a retrospective comparative study of consecutive patients undergoing ENB-CBCT and ssRAB-CBCT. Navigational success was defined as biopsy tool within lesion confirmed during CBJournal of thoracic disease5529-5538https://www.ebi.ac.uk/biostudies/studies/S-EPMC11494579biostudies-literatureCone-beam computed tomography-guided shape-sensing robotic bronchoscopy &lt;i&gt;vs.&lt;/i&gt; electromagnetic navigation bronchoscopy for pulmonary nodules.PMC11494579Espinoza DAbdelghani RBecnel DKheir FVillalobos RUribe JPHerr RfalseCone-beam computed tomography-guided shape-sensing robotic bronchoscopy &lt;i&gt;vs.&lt;/i&gt; electromagnetic navigation bronchoscopy for pulmonary nodules.<h4>Background</h4>Electromagnetic navigation bronchoscopy (ENB) and shape-sensing robotic-assisted bronchoscopy (ssRAB) are minimally invasive technologies for the diagnosis of pulmonary nodules. Cone-beam computed tomography (CBCT) has shown to increase diagnostic yield by allowing real-time confirmation of position of lesion and biopsy tool. There is a lack of comparative studies of such platforms using CBCT guidance to overcome computed tomography to body divergence. The aim of this study was to compare the diagnostic yield of ENB- and ssRAB-guided CBCT for biopsy of pulmonary nodules.<h4>Methods</h4>We conducted a retrospective comparative study of consecutive patients undergoing ENB-CBCT and ssRAB-CBCT. Navigational success was defined as biopsy tool within lesion confirmed during CB2024-01-01T00:00:00Z2024 Sep2025-04-26T00:19:16.658Z2025-04-06T09:40:57.734ZS-EPMC114945793944491110.21037/jtd-24-178