biostudies-literatureUnknown16(9)Rao R<h4>Background</h4>Trousseau syndrome (TS) refers to spontaneous, recurrent, and wandering arterial and venous thromboembolic events in patients with tumors. It results from abnormalities in coagulation and fibrinolytic mechanisms of varying degrees throughout the course of the disease. It has a high fatality rate, and it is commonly seen in patients with highly invasive tumors, such as lung, pancreatic, gastrointestinal, and breast cancers; however, to date, there has been no report of TS combined with chordoma.<h4>Case description</h4>A 56-year-old male with a diagnosis of chordoma underwent surgery, immunotherapy, immunotherapy combined with antiangiogenic therapy, chemotherapy combined with immunotherapy, and proton therapy for localized metastases. Subsequent to the worsening of chestJournal of thoracic disease6249-6262https://www.ebi.ac.uk/biostudies/studies/S-EPMC11494589biostudies-literatureChordoma combined with Trousseau syndrome: a case report and literature review.PMC11494589Lin PRao RMutoh TWang CChen YIto SYu ZXu JfalseChordoma combined with Trousseau syndrome: a case report and literature review.<h4>Background</h4>Trousseau syndrome (TS) refers to spontaneous, recurrent, and wandering arterial and venous thromboembolic events in patients with tumors. It results from abnormalities in coagulation and fibrinolytic mechanisms of varying degrees throughout the course of the disease. It has a high fatality rate, and it is commonly seen in patients with highly invasive tumors, such as lung, pancreatic, gastrointestinal, and breast cancers; however, to date, there has been no report of TS combined with chordoma.<h4>Case description</h4>A 56-year-old male with a diagnosis of chordoma underwent surgery, immunotherapy, immunotherapy combined with antiangiogenic therapy, chemotherapy combined with immunotherapy, and proton therapy for localized metastases. Subsequent to the worsening of chest2024-01-01T00:00:00Z2024 Sep2025-04-04T03:05:28.558Z2025-04-04T03:05:28.558ZS-EPMC114945893944488910.21037/jtd-24-1232