{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Poston TB"],"funding":["NIAID NIH HHS","National Institutes of Health"],"pagination":["1005-1018"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11495396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(5)"],"pubmed_abstract":["A vaccine is needed to combat the Chlamydia epidemic. Replication-deficient viral vectors are safe and induce antigen-specific T-cell memory. We tested the ability of intramuscular immunization with modified vaccinia Ankara (MVA) virus or chimpanzee adenovirus (ChAd) expressing chlamydial outer membrane protein (OmcB) or the secreted protein, chlamydial protease-like activating factor (CPAF), to enhance T-cell immunity and protection in mice previously infected with plasmid-deficient Chlamydia muridarum CM972 and elicit protection in naïve mice. MVA.OmcB or MVA.CPAF increased antigen-specific T cells in CM972-immune mice ∼150 and 50-fold, respectively, but failed to improve bacterial clearance. ChAd.OmcB/MVA.OmcB prime-boost immunization of naïve mice elicited a cluster of differentiation "],"journal":["Mucosal immunology"],"pubmed_title":["Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naive mice."],"pmcid":["PMC11495396"],"funding_grant_id":["U19 AI144181","U19 AI144181-01"],"pubmed_authors":["Beagley KW","Yount KS","Leahy D","Bhardwaj A","Girardi J","Jaras Salas I","Trim LK","O'Connell CM","Li Y","Polson AG","Darville T","Goonetilleke N","Harris JM","Poston TB"],"additional_accession":[]},"is_claimable":false,"name":"Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naive mice.","description":"A vaccine is needed to combat the Chlamydia epidemic. Replication-deficient viral vectors are safe and induce antigen-specific T-cell memory. We tested the ability of intramuscular immunization with modified vaccinia Ankara (MVA) virus or chimpanzee adenovirus (ChAd) expressing chlamydial outer membrane protein (OmcB) or the secreted protein, chlamydial protease-like activating factor (CPAF), to enhance T-cell immunity and protection in mice previously infected with plasmid-deficient Chlamydia muridarum CM972 and elicit protection in naïve mice. MVA.OmcB or MVA.CPAF increased antigen-specific T cells in CM972-immune mice ∼150 and 50-fold, respectively, but failed to improve bacterial clearance. ChAd.OmcB/MVA.OmcB prime-boost immunization of naïve mice elicited a cluster of differentiation ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-19T13:38:26.271Z","creation":"2025-04-19T13:38:26.271Z"},"accession":"S-EPMC11495396","cross_references":{"pubmed":["38969067"],"doi":["10.1016/j.mucimm.2024.06.012"]}}