{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song X"],"funding":["National Natural Science Foundation of China","Shanghai Municipal Key Clinical Specialty","National Key Research and Development Program of China","Biomaterials and Regenerative Medicine Institute Cooperative Research Project of Shanghai Jiao Tong University School of Medicine"],"pagination":["e2405420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11497002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(39)"],"pubmed_abstract":["Functional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue-engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi-tissue structure found in natural trachea. In this research, a multi-tissue integrated tissue-engineered trachea (MI-TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D-printed PGS bioelastomer scaffolds. The MI-TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C-shaped cartilage ring, O-shaped vascularized fiber ring, axial fiber bundle, and airway epitheli"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Multi-Tissue Integrated Tissue-Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds."],"pmcid":["PMC11497002"],"funding_grant_id":["2023YFC2417000","82102211","shslczdzk06601","2022LHA07"],"pubmed_authors":["Liu Y","Wang Q","Huang J","Wang S","Zhang Y","Qin X","Zhou G","Lei D","Song X","Li K","Luo B","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Multi-Tissue Integrated Tissue-Engineered Trachea Regeneration Based on 3D Printed Bioelastomer Scaffolds.","description":"Functional segmental trachea reconstruction is a critical concern in thoracic surgery, and tissue-engineered trachea (TET) holds promise as a potential solution. However, current TET falls short in fully restoring physiological function due to the lack of the intricate multi-tissue structure found in natural trachea. In this research, a multi-tissue integrated tissue-engineered trachea (MI-TET) is successfully developed by orderly assembling various cells (chondrocytes, fibroblasts and epithelial cells) on 3D-printed PGS bioelastomer scaffolds. The MI-TET closely resembles the complex structures of natural trachea and achieves the integrated regeneration of four essential tracheal components: C-shaped cartilage ring, O-shaped vascularized fiber ring, axial fiber bundle, and airway epitheli","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-19T13:39:32.573Z","creation":"2025-04-19T13:39:32.573Z"},"accession":"S-EPMC11497002","cross_references":{"pubmed":["39159156"],"doi":["10.1002/advs.202405420"]}}