biostudies-literatureZhang YJ2020 Li Ka Shing Foundation Cross-Disciplinary ResearchFirst Affiliated Hospital of Shantou University Medical College Supporting FundingGuangdong Basic and Applied Basic Research FoundationNatural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of ChinaScience and Technology of Guangdong Province6441-6455https://www.ebi.ac.uk/biostudies/studies/S-EPMC11497660biostudies-literatureUnknown20(9)<h4>Introduction</h4>The apolipoprotein E (APOE) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive.<h4>Methods</h4>The present study enrolled 54 patients diagnosed with late-onset Alzheimer's disease (AD; including 28 APOE ε4 carriers and 26 non-carriers). Plasma inflammatory cytokine concentration was assessed, alongside bulk RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) analysis of peripheral blood mononuclear cells (PBMCs).<h4>Results</h4>Plasma tumor necrosis factor α, interferon γ, and interleukin (IL)-33 levels increased in the APOE ε4 carriers but IL-7 expression notably decreased. A negative correlation was observed between plasma IL-7 level and the hippocampal atrophy degreeAlzheimer's & dementia : the journal of the Alzheimer's AssociationAPOE ε4-associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease.PMC114976602020LKSFG11C2023B151523000821072816690190682020108016202003-292214050005144STKJ202107582001447Wu JGuan JTYue QHou THuang KLin YCai XYCheng YWen YQZhang YJTang HLZheng WBLiu HXLu CHKong NJi XYLu ZJMa WYWu RHZeng XHao YXPan HXu SLWei NLDai AXfalseAPOE ε4-associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease.<h4>Introduction</h4>The apolipoprotein E (APOE) ε4 allele exerts a significant influence on peripheral inflammation and neuroinflammation, yet the underlying mechanisms remain elusive.<h4>Methods</h4>The present study enrolled 54 patients diagnosed with late-onset Alzheimer's disease (AD; including 28 APOE ε4 carriers and 26 non-carriers). Plasma inflammatory cytokine concentration was assessed, alongside bulk RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) analysis of peripheral blood mononuclear cells (PBMCs).<h4>Results</h4>Plasma tumor necrosis factor α, interferon γ, and interleukin (IL)-33 levels increased in the APOE ε4 carriers but IL-7 expression notably decreased. A negative correlation was observed between plasma IL-7 level and the hippocampal atrophy degree2024-01-01T00:00:00Z2024 Sep2025-04-26T00:15:57.242Z2025-04-06T09:39:52.492ZS-EPMC114976603912931010.1002/alz.14173