{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Institutes of Health"],"pagination":["104567"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11499005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111"],"pubmed_abstract":["Polychlorinated biphenyls (PCBs) and their metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6 J mice. Mice were exposed to 0.1, 1.0, or 6.0 mg/kg body weight/day of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples collected from the dams at weaning were analyzed using gas chromatograph-tandem mass spectrometry and nontarget liquid chromatography-high resolution mass spectrometry. Results showed complex and dose-dependent differences in PCB and metabolite profiles. Untargeted metabolomics revealed alterations in metabolites involved in glucuronidation. Network analysis suggested disturbances in heme and amino acid metabolism associated with higher chlorinated PCBs. These findings suggested that PCBs and metabolites present in the gestational and lactation environment of mice may contribute to developmental neurotoxicity in rodents."],"journal":["Environmental toxicology and pharmacology"],"pubmed_title":["Significant metabolic alterations in mouse dams exposed to an environmental mixture of polychlorinated biphenyls (PCBs) during gestation and lactation: Insights into PCB and metabolite profiles."],"pmcid":["PMC11499005"],"funding_grant_id":["R01ES014901","P42ES013661","R01 ES034691","P30 ES005605","R01 ES031098","R01ES031098","P42 ES013661","R01ES034691","P30ES005605","R01 ES014901"],"pubmed_authors":["Li X","Lein PJ","Suh YP","Wilson RJ","Lehmler HJ","Cui JY"],"additional_accession":[]},"is_claimable":false,"name":"Significant metabolic alterations in mouse dams exposed to an environmental mixture of polychlorinated biphenyls (PCBs) during gestation and lactation: Insights into PCB and metabolite profiles.","description":"Polychlorinated biphenyls (PCBs) and their metabolites are linked to developmental neurotoxicity, but their levels in the gestational and lactational environment remain unexplored. This study investigated the effects of dietary exposure to the Fox River Mixture (FRM) on serum levels of PCBs and their metabolites in female C57BL/6 J mice. Mice were exposed to 0.1, 1.0, or 6.0 mg/kg body weight/day of FRM beginning two weeks before mating and throughout gestation and lactation. Serum samples collected from the dams at weaning were analyzed using gas chromatograph-tandem mass spectrometry and nontarget liquid chromatography-high resolution mass spectrometry. Results showed complex and dose-dependent differences in PCB and metabolite profiles. Untargeted metabolomics revealed alterations in metabolites involved in glucuronidation. Network analysis suggested disturbances in heme and amino acid metabolism associated with higher chlorinated PCBs. These findings suggested that PCBs and metabolites present in the gestational and lactation environment of mice may contribute to developmental neurotoxicity in rodents.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-03T23:33:47.116Z","creation":"2026-05-03T03:11:36.271Z"},"accession":"S-EPMC11499005","cross_references":{"pubmed":["39305941"],"doi":["10.1016/j.etap.2024.104567"]}}