{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zou Z"],"funding":["NHLBI NIH HHS","NHGRI NIH HHS","NCI NIH HHS"],"pagination":["986-994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11499264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["634(8035)"],"pubmed_abstract":["Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression<sup>1-3</sup>. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant haematopoietic stem cell self-renewal<sup>4,5</sup>. However, the open chromatin observed in TET2-deficient mouse embryonic stem cells, leukaemic cells and haematopoietic stem and progenitor cells<sup>5</sup> is inconsistent with the designated role of DNA 5-methylcytosine oxidation of TET2. Here we show that chromatin-associated retrotransposon RNA 5-methylcytosine (m<sup>5</sup>C) can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A (H2AK119ub) to promot"],"journal":["Nature"],"pubmed_title":["RNA m&lt;sup&gt;5&lt;/sup&gt;C oxidation by TET2 regulates chromatin state and leukaemogenesis."],"pmcid":["PMC11499264"],"funding_grant_id":["R01 HL145883","R01 HL146664","R01 CA285299","R01 HL174477","RM1 HG008935"],"pubmed_authors":["Gao B","He C","Xu M","Hong J","Xiao Y","Sun C","Liu Q","Wang H","Wang J","Dou X","Zou Z","Li Y","Yang FC","Zhao L","Zhang Z","Dai Q","Wang Y","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"RNA m&lt;sup&gt;5&lt;/sup&gt;C oxidation by TET2 regulates chromatin state and leukaemogenesis.","description":"Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression<sup>1-3</sup>. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant haematopoietic stem cell self-renewal<sup>4,5</sup>. However, the open chromatin observed in TET2-deficient mouse embryonic stem cells, leukaemic cells and haematopoietic stem and progenitor cells<sup>5</sup> is inconsistent with the designated role of DNA 5-methylcytosine oxidation of TET2. Here we show that chromatin-associated retrotransposon RNA 5-methylcytosine (m<sup>5</sup>C) can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A (H2AK119ub) to promot","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T08:04:06.719Z","creation":"2025-04-04T23:32:25.855Z"},"accession":"S-EPMC11499264","cross_references":{"pubmed":["39358506"],"doi":["10.1038/s41586-024-07969-x"]}}