biostudies-literatureAppel KSJohann Wolfgang Goethe-Universität, Frankfurt am MainGerman Federal Ministry of Education and Research (BMBF) Network of University Medicine 2.0: "NUM 2.0"German Federal Ministry of Education and Research (BMBF) Network of University Medicine 2.0: “NUM 2.0&quot;1813-1829https://www.ebi.ac.uk/biostudies/studies/S-EPMC11499320biostudies-literatureUnknown52(5)<h4>Purpose</h4>The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score.<h4>Methods</h4>The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L).<h4>Results</h4>Six hundred three patients (mean 54.0 years,InfectionDefinition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON).PMC11499320Grant No. 01KX2121Knopp LHeuschmann PHeuschmann PUMeybohm PKlinsing SNussbeck SYSchreiber SHaas KGopel SWillam CArlt ATausche KAddo MWeinert NLorbeer RKrawczak MMaasjosthusmann PKonik MLaumerich BHerrmann JHagen MWeismantel CRoemmele CPrenzel RBrinkmann FBercker SSchulze PSchulze NStahl DHanses FHaertel CTamminga TScheer CKoerner MKrug NHansch SZeller TPolidori MCLorenz-Depiereux BSikdar SKienzle KJensen BOBellinghausen CZeh SBerner RMarx NWallner SIsberner NGruenewaldt ALuedde TKobbe RPape DBlaschke SPape CErber JGriesinger FHettich-Damm NMalek NDreher MBaber RChaplinskaya IAltmann HBrochhausen-Delius CGunther KStellbrink CMueller SDOtte MNurnberger CMuzalyova AKrefting DTimm JHamprecht AWilms CTorres Reyes CVollenberg REngelmann MKoch TBrohl IMiljukov OVehreschild JJLeppkes MHamelmann ESteinmann EBrochhagen LSchaller JKujat CSchuette CWagner PProkosch HUSantibanez-Santana MFiessler CSchunk DHaug FPaluschinski MElsner CHaug JHellwig KKhodamoradi YPetersen JNowacki TToepfner NSpinner CRuwe MOberlaender MKluge ABurkhardt RIllig TKerinn MSpieth PNiedermair TWitzke ODoerr MHeyder RKrawczyk AHanß SMuna ASeele KWolf KWolf LWitzenrath MNauck MFeldt TGroh ABunk SNAPKON Study GroupMaerkl BSchuster PJarczak DKrist LKraska DMeier JAKluge SRainers MBrechtel MHafke AWeigl MLieb JSeibel KFinke CWirtz HPetereit SHaag OSauer GBoeckel GBitzer MLieb WMitrov LDashti YPereira JPVMichler THoffmann WHopff SMScherer MArendt CBarkey WReinacher-Schick AHeidenreich HTepasse PRSilberbaur IDolff SFrey AGambichler TPlagge MFiedler KLiese JFrantz STrauner FDashti HMalfertheiner MMueller LLanger ADressen SPiasta NVogl TTessmer CGuenther UFriedrichs AKeitel VMeinhardt KNeurath MFLee CMeinhardt CVetter MStecher MCremer STebbe JJLindemann DSchneider JReese JPButzmann JJiru-Hillmann SSchaefer CMadel RJFeustel MPetersmann ASchaefer ERohde GJuergens KKremer AELuecke TKraus THermes ARonnefarth MKraus MSchmidt JKohls MSchattschneider MSchmidt SBader SRupp JMessmann Hde Miranda SMNBahls TStruemper CBonin SVBahmer TSchlesner CMueller-Wieland DBrueggemann YLemhofer CHornberg CMang JMahrhofer HVehreschild MRosenberger PDeckert JHerold SAlmahfoud MBecker KKaeding NSchmid JLutterbeck MHermanns GDahl EEngels ALFCleef SKulamadayil-Heidenreich NSAKiller AValentin HFricke JSchmidt WEVoit FWipperfuerth JAppel KSHaeberle HSchoneberg AFricke LAlsaad KWinter CSchmidbauer LForster CBuechner NLaugwitz MLehnert KGeisler RFuchs AfalseDefinition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON).<h4>Purpose</h4>The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score.<h4>Methods</h4>The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis. Scores indicative of PCS severity were compared and correlated to demographic and clinical characteristics as well as quality of life (QoL, EQ-5D-5L).<h4>Results</h4>Six hundred three patients (mean 54.0 years,2024-01-01T00:00:00Z2024 Oct2026-06-03T00:42:41.569Z2025-04-04T00:21:30.052ZS-EPMC114993203858775210.1007/s15010-024-02226-9