{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Voland RW"],"funding":["Department of Energy","NIGMS NIH HHS","National Science Foundation","NIGMS"],"pagination":["112682"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11501008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["260"],"pubmed_abstract":["The rate of photosynthesis and, thus, CO<sub>2</sub> fixation, is limited by the rate of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). Not only does Rubisco have a relatively low catalytic rate, but it also is promiscuous regarding the metal identity in the active site of the large subunit. In Nature, Rubisco binds either Mg(II) or Mn(II), depending on the chloroplastic ratio of these metal ions; most studies performed with Rubisco have focused on Mg-bound Rubisco. Herein, we report the first crystal structure of a Mn-bound Rubisco, and we compare its structural properties to those of its Mg-bound analogues."],"journal":["Journal of inorganic biochemistry"],"pubmed_title":["The structure of Mn(II)-bound Rubisco from Spinacia oleracea."],"pmcid":["PMC11501008"],"funding_grant_id":["R24 GM146107","P30 GM124165"],"pubmed_authors":["Voland RW","Lancaster KM","Coleman RE"],"additional_accession":[]},"is_claimable":false,"name":"The structure of Mn(II)-bound Rubisco from Spinacia oleracea.","description":"The rate of photosynthesis and, thus, CO<sub>2</sub> fixation, is limited by the rate of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). Not only does Rubisco have a relatively low catalytic rate, but it also is promiscuous regarding the metal identity in the active site of the large subunit. In Nature, Rubisco binds either Mg(II) or Mn(II), depending on the chloroplastic ratio of these metal ions; most studies performed with Rubisco have focused on Mg-bound Rubisco. Herein, we report the first crystal structure of a Mn-bound Rubisco, and we compare its structural properties to those of its Mg-bound analogues.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T09:29:49.648Z","creation":"2026-05-15T03:12:16.525Z"},"accession":"S-EPMC11501008","cross_references":{"pubmed":["39094246"],"doi":["10.1016/j.jinorgbio.2024.112682"]}}