biostudies-literatureKinsey JEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentLife Course Intervention Research NetworkNational Clinician’s Scholar Program and Cedars Sinai Medical CenterHealth Resources and Services Administration (HRSA) of the U.S. Department of Health and Human ServicesLife Course Translational Research Networke0307441https://www.ebi.ac.uk/biostudies/studies/S-EPMC11501017biostudies-literatureUnknown19(10)<h4>Background</h4>Preventing Adverse Childhood Experiences (ACEs) is a public health priority, and the perinatal period is a sensitive life stage when preventive interventions could be particularly effective. Protecting and buffering pregnant persons and infants from exposure to adversity can optimize children's development and health trajectories, reduce future morbidity and mortality, and even break intergenerational cycles of adversity, but no study has synthesized experimental evidence on effectiveness of interventions to address ACEs in the perinatal period.<h4>Objectives</h4>To (1) identify perinatal ACE prevention interventions, tested in high quality randomized control trials, with a dyadic perspective examining outcomes for mother and child; (2) describe their (a) place on the puPloS onePerinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review.PMC11501017UA6MC32492U9DMC49250K23HD099308Russ SSchickedanz ALa Charite JKinsey JfalsePerinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review.<h4>Background</h4>Preventing Adverse Childhood Experiences (ACEs) is a public health priority, and the perinatal period is a sensitive life stage when preventive interventions could be particularly effective. Protecting and buffering pregnant persons and infants from exposure to adversity can optimize children's development and health trajectories, reduce future morbidity and mortality, and even break intergenerational cycles of adversity, but no study has synthesized experimental evidence on effectiveness of interventions to address ACEs in the perinatal period.<h4>Objectives</h4>To (1) identify perinatal ACE prevention interventions, tested in high quality randomized control trials, with a dyadic perspective examining outcomes for mother and child; (2) describe their (a) place on the pu2024-01-01T00:00:00Z20242025-04-26T00:16:48.044Z2025-04-06T09:39:59.382ZS-EPMC115010173944690810.1371/journal.pone.0307441