{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(8)"],"submitter":["Li J"],"pubmed_abstract":["Spectral interference from backgrounds is not negligible for surface-enhanced Raman scattering (SERS) tags and often influences the accuracy and reliability of SERS applications. We report the design and synthesis of orthogonal gap-enhanced Raman tags (O-GERTs) by embedding alkyne and deuterium-based reporters in the interior metallic nanogaps of core-shell nanoparticles and explore their signal orthogonality as optical probes against different backgrounds from common substrates and media (e.g., glass and polymer) to related targets (e.g., bacteria, cancer cells, and tissues). Proof-of-concept experiments show that the O-GERT signals in the fingerprint region (200-1800 cm<sup>-1</sup>) are likely interfered by various backgrounds, leading to difficulty of accurate quantification, while the"],"journal":["Nanophotonics (Berlin, Germany)"],"pagination":["1549-1560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11501518"],"repository":["biostudies-literature"],"pubmed_title":["Orthogonal gap-enhanced Raman tags for interference-free and ultrastable surface-enhanced Raman scattering."],"pmcid":["PMC11501518"],"pubmed_authors":["He C","Li J","Liu F","Shen F","Ye J"],"additional_accession":[]},"is_claimable":false,"name":"Orthogonal gap-enhanced Raman tags for interference-free and ultrastable surface-enhanced Raman scattering.","description":"Spectral interference from backgrounds is not negligible for surface-enhanced Raman scattering (SERS) tags and often influences the accuracy and reliability of SERS applications. We report the design and synthesis of orthogonal gap-enhanced Raman tags (O-GERTs) by embedding alkyne and deuterium-based reporters in the interior metallic nanogaps of core-shell nanoparticles and explore their signal orthogonality as optical probes against different backgrounds from common substrates and media (e.g., glass and polymer) to related targets (e.g., bacteria, cancer cells, and tissues). Proof-of-concept experiments show that the O-GERT signals in the fingerprint region (200-1800 cm<sup>-1</sup>) are likely interfered by various backgrounds, leading to difficulty of accurate quantification, while the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-27T02:18:24.492Z","creation":"2025-04-06T18:31:29.245Z"},"accession":"S-EPMC11501518","cross_references":{"pubmed":["39635286"],"doi":["10.1515/nanoph-2021-0689"]}}