{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCracken C"],"funding":["Health Data Research UK","NIHR Integrated Academic Training","NIBIB NIH HHS","NIHR Oxford Biomedical Research Centre","Wellcome Trust","BHF Centre of Research Excellence, Oxford","UK Research and Innovation","NIHR Barts Biomedical Research Centre, Queen Mary University of London","HORIZON EUROPE Reforming and enhancing the European Research and Innovation system","BHF Clinical Research Training Fellowship"],"pagination":["313-323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11503151"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(5)"],"pubmed_abstract":["<h4>Objectives</h4>Despite rising rates of multimorbidity, existing risk assessment tools are mostly limited to a single outcome of interest. This study tests the feasibility of producing multiple disease risk estimates with at least 70% discrimination (area under the receiver operating curve, AUROC) within the time and information constraints of the existing primary care health check framework.<h4>Design</h4>Observational prospective cohort study SETTING: UK Biobank.<h4>Participants</h4>228 240 adults from the UK population.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>Myocardial infarction, atrial fibrillation, heart failure, stroke, all-cause dementia, chronic kidney disease, fatty liver disease, alcoholic liver disease, liver cirrhosis and liver failure.<h4>Results</h4>Using"],"journal":["BMJ evidence-based medicine"],"pubmed_title":["Feasibility of multiorgan risk prediction with routinely collected diagnostics: a prospective cohort study in the UK Biobank."],"pmcid":["PMC11503151"],"funding_grant_id":["203141/Z/16/Z","100309/Z/12/Z","N/A","RE/18/3/34214","R01 EB026859","FS/17/81/33318","MC_PC_20058","825903","206330/Z/17/Z","216462/Z/19/Z"],"pubmed_authors":["Roca-Fernandez A","Nichols TE","Topiwala A","Raisi-Estabragh Z","Szabo L","Neubauer S","Petersen SE","Husain M","McCracken C","Veldsman M","Raman B"],"additional_accession":[]},"is_claimable":false,"name":"Feasibility of multiorgan risk prediction with routinely collected diagnostics: a prospective cohort study in the UK Biobank.","description":"<h4>Objectives</h4>Despite rising rates of multimorbidity, existing risk assessment tools are mostly limited to a single outcome of interest. This study tests the feasibility of producing multiple disease risk estimates with at least 70% discrimination (area under the receiver operating curve, AUROC) within the time and information constraints of the existing primary care health check framework.<h4>Design</h4>Observational prospective cohort study SETTING: UK Biobank.<h4>Participants</h4>228 240 adults from the UK population.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>Myocardial infarction, atrial fibrillation, heart failure, stroke, all-cause dementia, chronic kidney disease, fatty liver disease, alcoholic liver disease, liver cirrhosis and liver failure.<h4>Results</h4>Using","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T03:04:05.937Z","creation":"2025-04-04T03:04:05.937Z"},"accession":"S-EPMC11503151","cross_references":{"pubmed":["38719437"],"doi":["10.1136/bmjebm-2023-112518"]}}