biostudies-literatureUnknown24(8)Matsumoto S<h4>Aim</h4>Patients with dementia with Lewy bodies (DLB) are at a high risk for falls and fractures. Although cholinesterase inhibitors reportedly are effective in suppressing the progression of cognitive symptoms in DLB patients, their effects on fracture risk remain unclarified. This study aimed to evaluate the association between donepezil use and hip fracture risk in older patients with DLB.<h4>Methods</h4>Using the Japanese insurance claim database, we collected the data of patients aged ≥65 years with DLB from April 2012 to March 2019. After propensity score matching, we compared the fracture rate over 3 years between DLB patients receiving donepezil and those not receiving antidementia drugs.<h4>Results</h4>Altogether, 24 022 239 individuals aged ≥65 years were newly registered froGeriatrics & gerontology international782-788https://www.ebi.ac.uk/biostudies/studies/S-EPMC11503602biostudies-literatureRelationship between donepezil and fracture risk in patients with dementia with Lewy bodies.PMC11503602Matsumoto STamaki JAkishita MIki MNakatoh SOkimoto NHosoi TFujimori KOgawa SYakabe MIshii SfalseRelationship between donepezil and fracture risk in patients with dementia with Lewy bodies.<h4>Aim</h4>Patients with dementia with Lewy bodies (DLB) are at a high risk for falls and fractures. Although cholinesterase inhibitors reportedly are effective in suppressing the progression of cognitive symptoms in DLB patients, their effects on fracture risk remain unclarified. This study aimed to evaluate the association between donepezil use and hip fracture risk in older patients with DLB.<h4>Methods</h4>Using the Japanese insurance claim database, we collected the data of patients aged ≥65 years with DLB from April 2012 to March 2019. After propensity score matching, we compared the fracture rate over 3 years between DLB patients receiving donepezil and those not receiving antidementia drugs.<h4>Results</h4>Altogether, 24 022 239 individuals aged ≥65 years were newly registered fro2024-01-01T00:00:00Z2024 Aug2025-04-19T13:39:48.785Z2025-04-19T13:39:48.785ZS-EPMC115036023892462110.1111/ggi.14929