{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li YY"],"funding":["National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["168-179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11504584"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(3)"],"pubmed_abstract":["Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE), a widely used flame retardant, has been frequently detected in various environmental compartments, but its health hazard remains largely unknown. Here, we investigated the adverse effects of TBBPA-BDBPE (50 and 1000 μg/kg/day) on postnatal testis development in CD-1 mice and the underlying mechanism. Following the first week of maternal exposure, neonatal mice in the high-dose group exhibited reduced seminiferous tubule area, fewer Sertoli cells and germ cells, and damaged microtubules in Sertoli cells; even microtubule damage was also observed in the low-dose group. When exposure extended to adulthood, male offspring in the high-dose group presented more remarkable alterations in reproductive parameters, including reduced s"],"journal":["Environment & health (Washington, D.C.)"],"pubmed_title":["Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) impairs Postnatal Testis Development in Mice: The Microtubule Cytoskeleton as a Sensitive Target."],"pmcid":["PMC11504584"],"funding_grant_id":["2018YFA0901103","21876196"],"pubmed_authors":["Xiong YM","Qin ZF","Deng JL","Xue Q","Li YY","Li XH","Liu WB","Zhang SY","Hou XW"],"additional_accession":[]},"is_claimable":false,"name":"Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) impairs Postnatal Testis Development in Mice: The Microtubule Cytoskeleton as a Sensitive Target.","description":"Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE), a widely used flame retardant, has been frequently detected in various environmental compartments, but its health hazard remains largely unknown. Here, we investigated the adverse effects of TBBPA-BDBPE (50 and 1000 μg/kg/day) on postnatal testis development in CD-1 mice and the underlying mechanism. Following the first week of maternal exposure, neonatal mice in the high-dose group exhibited reduced seminiferous tubule area, fewer Sertoli cells and germ cells, and damaged microtubules in Sertoli cells; even microtubule damage was also observed in the low-dose group. When exposure extended to adulthood, male offspring in the high-dose group presented more remarkable alterations in reproductive parameters, including reduced s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Sep","modification":"2026-07-15T17:42:50.697Z","creation":"2025-04-04T00:29:52.07Z"},"accession":"S-EPMC11504584","cross_references":{"pubmed":["39473615"],"doi":["10.1021/envhealth.3c00044"]}}