{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Couto-Lima CA"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP","Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq"],"pagination":["1258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11506464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(10)"],"pubmed_abstract":["EMC1 is part of the endoplasmic reticulum (ER) membrane protein complex, whose functions include the insertion of transmembrane proteins into the ER membrane, ER-mitochondria contact, and lipid exchange. Here, we show that the <i>Drosophila melanogaster EMC1</i> gene is expressed in the somatic musculature and the protein localizes to the sarcoplasmic reticulum (SR) network. Muscle-specific <i>EMC1</i> RNAi led to severe motility defects and partial late pupae/early adulthood lethality, phenotypes that are rescued by co-expression with an <i>EMC1</i> transgene. Motility impairment in EMC1-depleted flies was associated with aberrations in muscle morphology in embryos, larvae, and adults, including tortuous and misaligned fibers with reduced size and weakness. They were also associated with "],"journal":["Biomolecules"],"pubmed_title":["EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the &lt;i&gt;Drosophila&lt;/i&gt; Muscle."],"pmcid":["PMC11506464"],"funding_grant_id":["2016/16896-9","2014/18189-5","311347/2011-8","2022/05632-4","2013/21242-2","2015/13396-5","2021/06711-2","506780/2013-9","2012/17890-6","2011/50962-8","2004/08868-0","2009/54014-7","2010/17259-9","2011/16666-2","2010/11812-8"],"pubmed_authors":["Alberici LC","Trinca V","Anhezini L","Oliveira MT","Espreafico EM","Peixoto PM","Ramos RGP","Machado MCR","Molina RADS","Monesi N","Couto-Lima CA","da Silva RR","Lopes GS","Colon DF"],"additional_accession":[]},"is_claimable":false,"name":"EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the &lt;i&gt;Drosophila&lt;/i&gt; Muscle.","description":"EMC1 is part of the endoplasmic reticulum (ER) membrane protein complex, whose functions include the insertion of transmembrane proteins into the ER membrane, ER-mitochondria contact, and lipid exchange. Here, we show that the <i>Drosophila melanogaster EMC1</i> gene is expressed in the somatic musculature and the protein localizes to the sarcoplasmic reticulum (SR) network. Muscle-specific <i>EMC1</i> RNAi led to severe motility defects and partial late pupae/early adulthood lethality, phenotypes that are rescued by co-expression with an <i>EMC1</i> transgene. Motility impairment in EMC1-depleted flies was associated with aberrations in muscle morphology in embryos, larvae, and adults, including tortuous and misaligned fibers with reduced size and weakness. They were also associated with ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-03T23:51:28.465Z","creation":"2025-04-03T23:51:28.465Z"},"accession":"S-EPMC11506464","cross_references":{"pubmed":["39456191"],"doi":["10.3390/biom14101258"]}}