{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Wang Z"],"funding":["NIAID NIH HHS","NCI NIH HHS"],"pubmed_abstract":["The heterogeneity of epithelial-to-mesenchymal transition (EMT) programs is manifest in the diverse EMT-like phenotypes occurring during tumor progression. However, little is known about the mechanistic basis and functional role of specific forms of EMT in cancer. Here we address this question in lung adenocarcinoma (LUAD) cells that enter a dormancy period in response to TGF-β upon disseminating to distant sites. LUAD cells with the capacity to enter dormancy are characterized by expression of SOX2 and NKX2-1 primitive progenitor markers. In these cells, TGF-β induces growth inhibition accompanied by a full EMT response that subsequently transitions into an atypical mesenchymal state of round morphology and lacking actin stress fibers. TGF-β induces this transition by driving the expressi"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.15.618357"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11507679"],"repository":["biostudies-literature"],"pubmed_title":["TGF-β induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis."],"pmcid":["PMC11507679"],"funding_grant_id":["R01 AI087644","R35 CA252978","P30 CA008748","R01 CA266068","P01 CA129243","T32 CA254875"],"pubmed_authors":["Lampe G","Godet I","Xavier J","Massague J","Peters L","Chen Y","Wang Z","Elbanna Y","Huse M"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.","description":"The heterogeneity of epithelial-to-mesenchymal transition (EMT) programs is manifest in the diverse EMT-like phenotypes occurring during tumor progression. However, little is known about the mechanistic basis and functional role of specific forms of EMT in cancer. Here we address this question in lung adenocarcinoma (LUAD) cells that enter a dormancy period in response to TGF-β upon disseminating to distant sites. LUAD cells with the capacity to enter dormancy are characterized by expression of SOX2 and NKX2-1 primitive progenitor markers. In these cells, TGF-β induces growth inhibition accompanied by a full EMT response that subsequently transitions into an atypical mesenchymal state of round morphology and lacking actin stress fibers. TGF-β induces this transition by driving the expressi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-07T03:20:37.407Z","creation":"2025-04-04T00:27:34.53Z"},"accession":"S-EPMC11507679","cross_references":{"pubmed":["39463937"],"doi":["10.1101/2024.10.15.618357"]}}