{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Tiwari M"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic proteins with a single fucose (O-Fuc). A nucleocytoplasmic O-fucosyltransferase (OFT) occurs in the pathogen <i>Toxoplasma gondii</i>, the social amoeba <i>Dictyostelium</i>, and higher plants, where it is called Spy because mutants have a spindly appearance. O-fucosylation, which is required for optimal proliferation of <i>Toxoplasma</i> and <i>Dictyostelium</i>, is paralogous to the O-GlcNAcylation of nucleocytoplasmic proteins of plants and animals that is involved in stress and nutritional responses. O-Fuc was first discovered in <i>Toxopl"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.15.618526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11507795"],"repository":["biostudies-literature"],"pubmed_title":["Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants."],"pmcid":["PMC11507795"],"funding_grant_id":["R01 GM129324","R35 GM148433","T32 AI060546"],"pubmed_authors":["Samuelson J","Olszewski N","Goyal M","Haltiwanger RS","Matsumoto K","West CM","Gas-Pascual E","Grafe M","Orlando R","Tiwari M","Graf R","Popov M"],"additional_accession":[]},"is_claimable":false,"name":"Novel antibodies detect nucleocytoplasmic O-fucose in protist pathogens, cellular slime molds, and plants.","description":"Cellular adaptations to change often involve post-translational modifications of nuclear and cytoplasmic proteins. An example found in protists and plants is the modification of serine and threonine residues of dozens to hundreds of nucleocytoplasmic proteins with a single fucose (O-Fuc). A nucleocytoplasmic O-fucosyltransferase (OFT) occurs in the pathogen <i>Toxoplasma gondii</i>, the social amoeba <i>Dictyostelium</i>, and higher plants, where it is called Spy because mutants have a spindly appearance. O-fucosylation, which is required for optimal proliferation of <i>Toxoplasma</i> and <i>Dictyostelium</i>, is paralogous to the O-GlcNAcylation of nucleocytoplasmic proteins of plants and animals that is involved in stress and nutritional responses. O-Fuc was first discovered in <i>Toxopl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-01T03:17:45.719Z","creation":"2025-04-06T01:57:36.98Z"},"accession":"S-EPMC11507795","cross_references":{"pubmed":["39464065"],"doi":["10.1101/2024.10.15.618526"]}}