{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(20)"],"submitter":["Lee MF"],"pubmed_abstract":["Inflammation plays a crucial role in atherosclerosis and nonalcoholic fatty liver disease (NAFLD). We previously engineered a recombinant <i>Lactococcus lactis</i> strain expressing the Ling-Zhi immunomodulatory protein (<i>L. lactis</i>-LZ8). This study investigated the anti-atherosclerotic effects of <i>L. lactis</i>-LZ8 in rabbits fed a high-fat diet (HFD). Changes in body weight, serum lipid profiles, and liver function were monitored. The aorta and liver tissues were analyzed for gross pathology and histopathology. Eight-week administration of <i>L. lactis</i>-LZ8 with HFD ameliorated atherosclerosis by downregulating protein and gene expression associated with lipid metabolism and inflammation in the aortas. The rabbits receiving <i>L. lactis</i>-LZ8 exhibited a significant dose-depe"],"journal":["International journal of molecular sciences"],"pagination":["11278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11508337"],"repository":["biostudies-literature"],"pubmed_title":["The Anti-Inflammatory Effect of &lt;i&gt;Lactococcus lactis&lt;/i&gt;-Ling-Zhi 8 on Ameliorating Atherosclerosis and Nonalcoholic Fatty Liver in High-Fat Diet Rabbits."],"pmcid":["PMC11508337"],"pubmed_authors":["Lee MF","Lin WW","Wang NM","Chu YW","Wu CS"],"additional_accession":[]},"is_claimable":false,"name":"The Anti-Inflammatory Effect of &lt;i&gt;Lactococcus lactis&lt;/i&gt;-Ling-Zhi 8 on Ameliorating Atherosclerosis and Nonalcoholic Fatty Liver in High-Fat Diet Rabbits.","description":"Inflammation plays a crucial role in atherosclerosis and nonalcoholic fatty liver disease (NAFLD). We previously engineered a recombinant <i>Lactococcus lactis</i> strain expressing the Ling-Zhi immunomodulatory protein (<i>L. lactis</i>-LZ8). This study investigated the anti-atherosclerotic effects of <i>L. lactis</i>-LZ8 in rabbits fed a high-fat diet (HFD). Changes in body weight, serum lipid profiles, and liver function were monitored. The aorta and liver tissues were analyzed for gross pathology and histopathology. Eight-week administration of <i>L. lactis</i>-LZ8 with HFD ameliorated atherosclerosis by downregulating protein and gene expression associated with lipid metabolism and inflammation in the aortas. The rabbits receiving <i>L. lactis</i>-LZ8 exhibited a significant dose-depe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:21:26.145Z","creation":"2025-04-04T02:21:26.145Z"},"accession":"S-EPMC11508337","cross_references":{"pubmed":["39457059"],"doi":["10.3390/ijms252011278"]}}