{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hesse C"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["11133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11508481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(20)"],"pubmed_abstract":["Tegaserod (1-{[(5-methoxy-1H-indol-3-yl)methyliden]amino}-3-pentylguanidine) is a potent agonist at human recombinant 5-HT<sub>4</sub> serotonin receptors. Consequently, tegaserod is utilized in the treatment of bowel diseases. The objective of this study was to test the hypothesis that tegaserod stimulates human cardiac atrial 5-HT<sub>4</sub>-receptors via cyclic adenosine monophosphate (cAMP)-dependent pathways. Tegaserod exerted positive inotropic effects (PIEs) and positive chronotropic effects (PCEs) in isolated left and right atrial preparations, respectively, from mice with cardiac-specific overexpression of the human 5-HT<sub>4</sub> serotonin receptor (5-HT<sub>4</sub>-TG) in a concentration- and time-dependent manner. However, no effect was observed in the hearts of littermates "],"journal":["International journal of molecular sciences"],"pubmed_title":["Tegaserod Stimulates 5-HT&lt;sub&gt;4&lt;/sub&gt; Serotonin Receptors in the Isolated Human Atrium."],"pmcid":["PMC11508481"],"funding_grant_id":["PO732"],"pubmed_authors":["Muller FE","Neumann J","Compan V","Ponimaskin E","Hofmann B","Hesse C","Gergs U"],"additional_accession":[]},"is_claimable":false,"name":"Tegaserod Stimulates 5-HT&lt;sub&gt;4&lt;/sub&gt; Serotonin Receptors in the Isolated Human Atrium.","description":"Tegaserod (1-{[(5-methoxy-1H-indol-3-yl)methyliden]amino}-3-pentylguanidine) is a potent agonist at human recombinant 5-HT<sub>4</sub> serotonin receptors. Consequently, tegaserod is utilized in the treatment of bowel diseases. The objective of this study was to test the hypothesis that tegaserod stimulates human cardiac atrial 5-HT<sub>4</sub>-receptors via cyclic adenosine monophosphate (cAMP)-dependent pathways. Tegaserod exerted positive inotropic effects (PIEs) and positive chronotropic effects (PCEs) in isolated left and right atrial preparations, respectively, from mice with cardiac-specific overexpression of the human 5-HT<sub>4</sub> serotonin receptor (5-HT<sub>4</sub>-TG) in a concentration- and time-dependent manner. However, no effect was observed in the hearts of littermates ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-26T00:12:55.475Z","creation":"2025-04-06T09:42:29.914Z"},"accession":"S-EPMC11508481","cross_references":{"pubmed":["39456915"],"doi":["10.3390/ijms252011133"]}}