{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ge J"],"funding":["Natural Science Foundation of Henan Province;Science and Technology Research and Development Plan Joint Fund Project of Henan Province;Scientific and Technological Projects Entrusted by Enterprises"],"pagination":["2093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11509934"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["Fusarium head blight in wheat is mainly caused by <i>Fusarium graminearum</i> and results in significant economic losses. Coenzyme Q (CoQ) is ubiquitously produced across organisms and functions as a hydrogen carrier in energy metabolism. While UbiH in <i>Escherichia coli</i> serves as a hydroxylase in CoQ biosynthesis, its role in phytopathogenic fungi is not well understood. This study explored the role of the hydroxylase FgUbiH in <i>F. graminearum</i>. Using a <i>FgUbiH</i> deletion mutant, we observed reduced hyphal growth, conidial production, germination, toxin synthesis, and pathogenicity compared to the wild-type. A transcriptome analysis indicated <i>FgUbiH</i>'s involvement in regulating carbohydrate and amino acid metabolism. Deletion of <i>FgUbiH</i> impaired mitochondrial fun"],"journal":["Microorganisms"],"pubmed_title":["FgUbiH Is Essential for Vegetative Development, Energy Metabolism, and Antioxidant Activity in &lt;i&gt;Fusarium graminearum&lt;/i&gt;."],"pmcid":["PMC11509934"],"funding_grant_id":["242300421106; 222103810063; H2022sw175"],"pubmed_authors":["Ma P","Tang L","Hu Y","Zhai H","Lv Y","Wei S","Lei Y","Ge J","Zhao F","Zhang S","Zhou Y","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"FgUbiH Is Essential for Vegetative Development, Energy Metabolism, and Antioxidant Activity in &lt;i&gt;Fusarium graminearum&lt;/i&gt;.","description":"Fusarium head blight in wheat is mainly caused by <i>Fusarium graminearum</i> and results in significant economic losses. Coenzyme Q (CoQ) is ubiquitously produced across organisms and functions as a hydrogen carrier in energy metabolism. While UbiH in <i>Escherichia coli</i> serves as a hydroxylase in CoQ biosynthesis, its role in phytopathogenic fungi is not well understood. This study explored the role of the hydroxylase FgUbiH in <i>F. graminearum</i>. Using a <i>FgUbiH</i> deletion mutant, we observed reduced hyphal growth, conidial production, germination, toxin synthesis, and pathogenicity compared to the wild-type. A transcriptome analysis indicated <i>FgUbiH</i>'s involvement in regulating carbohydrate and amino acid metabolism. Deletion of <i>FgUbiH</i> impaired mitochondrial fun","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-19T13:39:26.047Z","creation":"2025-04-19T13:39:26.047Z"},"accession":"S-EPMC11509934","cross_references":{"pubmed":["39458403"],"doi":["10.3390/microorganisms12102093"]}}