{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao J"],"funding":["Jilin Province Science and Technology Development Project"],"pagination":["1349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11510286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(10)"],"pubmed_abstract":["<b>Background:</b> Obesity is gradually becoming a widespread health problem, and treatment using natural compounds has seen an increasing trend. As a by-product of hazelnut, hazel leaf is usually disposed of as waste, but it is widely used in traditional and folk medicines around the world. <b>Aim of this study:</b> Based on previous studies, the effects of the regulation of lipid metabolism and the mechanism of hazel leaf polyphenol extraction obesity were investigated. <b>Methods:</b> In this study, a high-fat diet-fed mouse model of obesity and 3T3-L1 preadipocytes were established. The ameliorative effects of the hazel leaf polyphenol extract on obesity and the regulating lipid metabolisms were explored based on network pharmacology, gut microbiota, and molecular docking. <b>Results:<"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols."],"pmcid":["PMC11510286"],"funding_grant_id":["20230204006YY"],"pubmed_authors":["Li Y","Li J","Lv G","Lin H","Lin Z","Wang X","Alimu A","Wang Y","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Potential Anti-Obesity Effect of Hazel Leaf Extract in Mice and Network Pharmacology of Selected Polyphenols.","description":"<b>Background:</b> Obesity is gradually becoming a widespread health problem, and treatment using natural compounds has seen an increasing trend. As a by-product of hazelnut, hazel leaf is usually disposed of as waste, but it is widely used in traditional and folk medicines around the world. <b>Aim of this study:</b> Based on previous studies, the effects of the regulation of lipid metabolism and the mechanism of hazel leaf polyphenol extraction obesity were investigated. <b>Methods:</b> In this study, a high-fat diet-fed mouse model of obesity and 3T3-L1 preadipocytes were established. The ameliorative effects of the hazel leaf polyphenol extract on obesity and the regulating lipid metabolisms were explored based on network pharmacology, gut microbiota, and molecular docking. <b>Results:<","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-04-22T03:13:39.733Z","creation":"2025-04-04T00:21:28.097Z"},"accession":"S-EPMC11510286","cross_references":{"pubmed":["39458990"],"doi":["10.3390/ph17101349"]}}