{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(10)"],"submitter":["Chim SM"],"funding":["Regeneron Pharmaceuticals, Inc."],"pubmed_abstract":["<b>Background/Objectives:</b> The limited translatability of preclinical experimental findings to patients remains an obstacle for successful treatment of brain diseases. Relevant models to elucidate mechanisms behind brain pathogenesis, including cell-specific contributions and cell-cell interactions, and support successful targeting and prediction of drug responses in humans are urgently needed, given the species differences in brain and blood-brain barrier (BBB) functions. Human microphysiological systems (MPS), such as Organ-Chips, are emerging as a promising approach to address these challenges. Here, we examined and advanced a Brain-Chip that recapitulates aspects of the human cortical parenchyma and the BBB in one model. <b>Methods:</b> We utilized human primary astrocytes and peric"],"journal":["Pharmaceutics"],"pagination":["1314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11510380"],"repository":["biostudies-literature"],"pubmed_title":["A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood-Brain Barrier Crossing Therapeutic Strategies."],"pmcid":["PMC11510380"],"pubmed_authors":["Zambrowicz B","Chim SM","Karalis K","Howell K","Kokkosis A","Pavlopoulos E"],"additional_accession":[]},"is_claimable":false,"name":"A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood-Brain Barrier Crossing Therapeutic Strategies.","description":"<b>Background/Objectives:</b> The limited translatability of preclinical experimental findings to patients remains an obstacle for successful treatment of brain diseases. Relevant models to elucidate mechanisms behind brain pathogenesis, including cell-specific contributions and cell-cell interactions, and support successful targeting and prediction of drug responses in humans are urgently needed, given the species differences in brain and blood-brain barrier (BBB) functions. Human microphysiological systems (MPS), such as Organ-Chips, are emerging as a promising approach to address these challenges. Here, we examined and advanced a Brain-Chip that recapitulates aspects of the human cortical parenchyma and the BBB in one model. <b>Methods:</b> We utilized human primary astrocytes and peric","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T03:03:45.807Z","creation":"2025-04-04T03:03:45.807Z"},"accession":"S-EPMC11510380","cross_references":{"pubmed":["39458643"],"doi":["10.3390/pharmaceutics16101314"]}}