{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Othaim AA"],"funding":["Prince Sattam bin Abdulaziz University"],"pagination":["1263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11510541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(10)"],"pubmed_abstract":["<h4>Background/objectives</h4><i>PRKACA</i> alterations have clear diagnostic and biological roles in the fibrolamellar variant of hepatocellular carcinoma and a potential predictive role in that cancer type. However, the roles of <i>PRKACA</i> have not been comprehensively examined in gastric and colorectal cancers (GC and CRC). This study, therefore, sought to investigate the roles of <i>PRKACA</i> expression in GC and CRC.<h4>Methods</h4>The clinico-genomic data of 441 GC and 629 CRC cases were analyzed for therapeutic, clinicopathological, and biological correlates using appropriate bioinformatics and statistical tools. Furthermore, the deregulation of <i>PRKACA</i> expression in GC and CRC was investigated using correlative and regression analyses.<h4>Results</h4>The results showed th"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Therapeutic, Clinicopathological, and Molecular Correlates of <i>PRKACA</i> Expression in Gastrointestinal Cancers."],"pmcid":["PMC11510541"],"funding_grant_id":["PSAU/2023/R/1445"],"pubmed_authors":["Othaim AA","Alfahed A","Alasiri G"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic, Clinicopathological, and Molecular Correlates of <i>PRKACA</i> Expression in Gastrointestinal Cancers.","description":"<h4>Background/objectives</h4><i>PRKACA</i> alterations have clear diagnostic and biological roles in the fibrolamellar variant of hepatocellular carcinoma and a potential predictive role in that cancer type. However, the roles of <i>PRKACA</i> have not been comprehensively examined in gastric and colorectal cancers (GC and CRC). This study, therefore, sought to investigate the roles of <i>PRKACA</i> expression in GC and CRC.<h4>Methods</h4>The clinico-genomic data of 441 GC and 629 CRC cases were analyzed for therapeutic, clinicopathological, and biological correlates using appropriate bioinformatics and statistical tools. Furthermore, the deregulation of <i>PRKACA</i> expression in GC and CRC was investigated using correlative and regression analyses.<h4>Results</h4>The results showed th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-04-08T19:26:09.834Z","creation":"2025-04-19T17:26:06.363Z"},"accession":"S-EPMC11510541","cross_references":{"pubmed":["39458904"],"doi":["10.3390/ph17101263"]}}