biostudies-literatureOthaim AAPrince Sattam bin Abdulaziz University1263https://www.ebi.ac.uk/biostudies/studies/S-EPMC11510541biostudies-literatureUnknown17(10)<h4>Background/objectives</h4><i>PRKACA</i> alterations have clear diagnostic and biological roles in the fibrolamellar variant of hepatocellular carcinoma and a potential predictive role in that cancer type. However, the roles of <i>PRKACA</i> have not been comprehensively examined in gastric and colorectal cancers (GC and CRC). This study, therefore, sought to investigate the roles of <i>PRKACA</i> expression in GC and CRC.<h4>Methods</h4>The clinico-genomic data of 441 GC and 629 CRC cases were analyzed for therapeutic, clinicopathological, and biological correlates using appropriate bioinformatics and statistical tools. Furthermore, the deregulation of <i>PRKACA</i> expression in GC and CRC was investigated using correlative and regression analyses.<h4>Results</h4>The results showed thPharmaceuticals (Basel, Switzerland)Therapeutic, Clinicopathological, and Molecular Correlates of <i>PRKACA</i> Expression in Gastrointestinal Cancers.PMC11510541PSAU/2023/R/1445Othaim AAAlfahed AAlasiri GfalseTherapeutic, Clinicopathological, and Molecular Correlates of <i>PRKACA</i> Expression in Gastrointestinal Cancers.<h4>Background/objectives</h4><i>PRKACA</i> alterations have clear diagnostic and biological roles in the fibrolamellar variant of hepatocellular carcinoma and a potential predictive role in that cancer type. However, the roles of <i>PRKACA</i> have not been comprehensively examined in gastric and colorectal cancers (GC and CRC). This study, therefore, sought to investigate the roles of <i>PRKACA</i> expression in GC and CRC.<h4>Methods</h4>The clinico-genomic data of 441 GC and 629 CRC cases were analyzed for therapeutic, clinicopathological, and biological correlates using appropriate bioinformatics and statistical tools. Furthermore, the deregulation of <i>PRKACA</i> expression in GC and CRC was investigated using correlative and regression analyses.<h4>Results</h4>The results showed th2024-01-01T00:00:00Z2024 Sep2026-04-08T19:26:09.834Z2025-04-19T17:26:06.363ZS-EPMC115105413945890410.3390/ph17101263