{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(10)"],"submitter":["Moldovan CV"],"pubmed_abstract":["<b>Background:</b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is considered the main cause of nosocomial and community-associated infections. Because of antimicrobial resistance, MRSA infections are difficult or impossible to treat, leading to high mortality rates and significant economic and societal costs. In view of the MRSA challenge to public health all over the world, the identification of new and effective anti-MRSA agents is a high medical priority. <b>Objectives:</b> A new series of tricyclic flavonoids with a methyl substituent on ring A of the flavonoid skeleton was synthesized to assess their antimicrobial properties. <b>Methods:</b> The structures of novel synthetic tricyclic flavonoids and their 3-dithiocarbamic flavanones were proven by X-ray structural analys"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pagination":["1276"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11510641"],"repository":["biostudies-literature"],"pubmed_title":["Novel Tricyclic Flavonoids as Promising Anti-MRSA Agents."],"pmcid":["PMC11510641"],"pubmed_authors":["Mantea LE","Jones PG","Birsa ML","Stefan M","Sarbu LG","Moldovan CV","Savu M"],"additional_accession":[]},"is_claimable":false,"name":"Novel Tricyclic Flavonoids as Promising Anti-MRSA Agents.","description":"<b>Background:</b> Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is considered the main cause of nosocomial and community-associated infections. Because of antimicrobial resistance, MRSA infections are difficult or impossible to treat, leading to high mortality rates and significant economic and societal costs. In view of the MRSA challenge to public health all over the world, the identification of new and effective anti-MRSA agents is a high medical priority. <b>Objectives:</b> A new series of tricyclic flavonoids with a methyl substituent on ring A of the flavonoid skeleton was synthesized to assess their antimicrobial properties. <b>Methods:</b> The structures of novel synthetic tricyclic flavonoids and their 3-dithiocarbamic flavanones were proven by X-ray structural analys","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T03:04:31.07Z","creation":"2025-04-04T03:04:31.07Z"},"accession":"S-EPMC11510641","cross_references":{"pubmed":["39458917"],"doi":["10.3390/ph17101276"]}}