{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luddecke T"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Federal Ministry of Science and Education","European Cooperation in Science and Technology","Hessisches Ministerium für Wissenschaft und Kunst","LOEWE Centre for Translational Biodiversity Genomics"],"pagination":["438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11511112"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(10)"],"pubmed_abstract":["\"True\" cobras (genus <i>Naja</i>) are among the venomous snakes most frequently involved in snakebite accidents in Africa and Asia. The Cape cobra (<i>Naja nivea</i>) is one of the African cobras of highest medical importance, but much remains to be learned about its venom. Here, we used a shotgun proteomics approach to better understand the qualitative composition of <i>N. nivea</i> venom and tested its cytotoxicity and protease activity as well as its effect on intracellular Ca<sup>2+</sup> release and NO synthesis. We identified 156 venom components representing 17 protein families, with the dominant ones being three-finger toxins, mostly of the short-chain type. Two-thirds of the three-finger toxin entries identified were assigned as cytotoxins, while the remainder were categorized as "],"journal":["Toxins"],"pubmed_title":["The Toxin Diversity, Cytotoxicity, and Enzymatic Activity of Cape Cobra (&lt;i&gt;Naja nivea&lt;/i&gt;) Venom."],"pmcid":["PMC11511112"],"funding_grant_id":["540833593","505696476","545040837","01KI2024","LOEWE-TBG"],"pubmed_authors":["Luddecke T","Henke M","Avella I","Eichberg J","Schulte L","Schiffmann S","Timm T","Damm M","Lochnit G","Hardes K","Vilcinskas A"],"additional_accession":[]},"is_claimable":false,"name":"The Toxin Diversity, Cytotoxicity, and Enzymatic Activity of Cape Cobra (&lt;i&gt;Naja nivea&lt;/i&gt;) Venom.","description":"\"True\" cobras (genus <i>Naja</i>) are among the venomous snakes most frequently involved in snakebite accidents in Africa and Asia. The Cape cobra (<i>Naja nivea</i>) is one of the African cobras of highest medical importance, but much remains to be learned about its venom. Here, we used a shotgun proteomics approach to better understand the qualitative composition of <i>N. nivea</i> venom and tested its cytotoxicity and protease activity as well as its effect on intracellular Ca<sup>2+</sup> release and NO synthesis. We identified 156 venom components representing 17 protein families, with the dominant ones being three-finger toxins, mostly of the short-chain type. Two-thirds of the three-finger toxin entries identified were assigned as cytotoxins, while the remainder were categorized as ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-04-19T03:22:09.64Z","creation":"2025-04-04T00:30:03.057Z"},"accession":"S-EPMC11511112","cross_references":{"pubmed":["39453214"],"doi":["10.3390/toxins16100438"]}}