{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(10)"],"submitter":["Diep NV"],"funding":["AVAC JSC"],"pubmed_abstract":["<b>Background</b>: African swine fever virus (ASFV) continues to spread globally, causing severe economic losses to pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF to control the ongoing ASF outbreaks. In 2023, newly emerging highly virulent recombinant ASF viruses (rASFV I/II) containing genetic elements from both p72 genotype I and II ASF viruses were reported from Northern Vietnam. <b>Objective</b>: This study evaluated whether the two vaccine strains were able to protect the pigs against the emerging rASFV I/II strain VNUA/rASFV/TN1/23. <b>Results</b>: Pigs vaccinated with ASFV-G-ΔMGF or ASFV-G-ΔI177L, when challenged with rASFV I/II, succumbed to the infection, or developed signs of chronic ASF. <b>Conclusions</b>: The"],"journal":["Vaccines"],"pagination":["1114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11511409"],"repository":["biostudies-literature"],"pubmed_title":["Genotype II Live-Attenuated ASFV Vaccine Strains Unable to Completely Protect Pigs against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam."],"pmcid":["PMC11511409"],"pubmed_authors":["Tiep TN","Nguyen VD","Duc NV","Than TT","Dang VX","Goonewardene K","Ngoc NT","Maydaniuk D","Le VP","Ambagala A","Diep NV"],"additional_accession":[]},"is_claimable":false,"name":"Genotype II Live-Attenuated ASFV Vaccine Strains Unable to Completely Protect Pigs against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam.","description":"<b>Background</b>: African swine fever virus (ASFV) continues to spread globally, causing severe economic losses to pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF to control the ongoing ASF outbreaks. In 2023, newly emerging highly virulent recombinant ASF viruses (rASFV I/II) containing genetic elements from both p72 genotype I and II ASF viruses were reported from Northern Vietnam. <b>Objective</b>: This study evaluated whether the two vaccine strains were able to protect the pigs against the emerging rASFV I/II strain VNUA/rASFV/TN1/23. <b>Results</b>: Pigs vaccinated with ASFV-G-ΔMGF or ASFV-G-ΔI177L, when challenged with rASFV I/II, succumbed to the infection, or developed signs of chronic ASF. <b>Conclusions</b>: The","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-07-07T03:18:23.302Z","creation":"2026-07-07T03:10:47.438Z"},"accession":"S-EPMC11511409","cross_references":{"pubmed":["39460281"],"doi":["10.3390/vaccines12101114"]}}