biostudies-literatureJayani RVNIA NIH HHSNational Institutes of HealthNIH HHSUniHealth Foundation3894-3901https://www.ebi.ac.uk/biostudies/studies/S-EPMC11511632biostudies-literatureUnknown130(22)<h4>Background</h4>Depression and anxiety are prevalent in older adults with cancer but are often undertreated. Older adults are also at increased risk of chemotherapy toxicity (CT). This study evaluated the impact of depression and anxiety symptoms on severe CT risk in older adults with cancer.<h4>Methods</h4>This is a secondary analysis of a randomized trial (2:1) evaluating geriatric assessment-driven intervention (GAIN) versus standard of care (SOC) to reduce grade 3+ CT in older adults with cancer. Mental health was assessed via the Mental Health Inventory 13. CT was graded by National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0.<h4>Results</h4>A total of 605 patients enrolled (402 GAIN; 203 SOC). Overall, 35% were depressed and 47% were anxious. PatieCancerThe relationship of mental health symptoms to chemotherapy toxicity risk in older adults with cancer: Results from the geriatric assessment-driven intervention study.PMC11511632K24AG055693R33 AG059206R33AG059206K24 AG055693Cabrera Chien LHamparsumian ALi DFernandes Dos Santos Hughes SKatheria VSun CMoreno JJayani RVTaylor WDDale WfalseThe relationship of mental health symptoms to chemotherapy toxicity risk in older adults with cancer: Results from the geriatric assessment-driven intervention study.<h4>Background</h4>Depression and anxiety are prevalent in older adults with cancer but are often undertreated. Older adults are also at increased risk of chemotherapy toxicity (CT). This study evaluated the impact of depression and anxiety symptoms on severe CT risk in older adults with cancer.<h4>Methods</h4>This is a secondary analysis of a randomized trial (2:1) evaluating geriatric assessment-driven intervention (GAIN) versus standard of care (SOC) to reduce grade 3+ CT in older adults with cancer. Mental health was assessed via the Mental Health Inventory 13. CT was graded by National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0.<h4>Results</h4>A total of 605 patients enrolled (402 GAIN; 203 SOC). Overall, 35% were depressed and 47% were anxious. Patie2024-01-01T00:00:00Z2024 Nov2026-07-15T07:39:47.315Z2026-07-01T03:07:46.119ZS-EPMC115116323909780110.1002/cncr.35482