{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2024"],"submitter":["Li Z"],"pubmed_abstract":["<b>Background:</b> Neuroblastoma (NB) is one of the most devastating malignancies in children, accounting for a high mortality rate due to limited treatment options. This study is aimed at elucidating the role of the ferroptosis-related EIF2S1 gene in NB pathogenesis and exploring its potential as a therapeutic target. <b>Methods:</b> We conducted comprehensive bioinformatics analyses utilizing the FerrDb database and NB-related transcriptomics data to investigate the role of EIF2S1 in NB. Changes in EIF2S1 expression were subsequently validated in NB tissues and cell lines. Loss-of-function experiments were performed in SK-N-SH and IMR-32 cell lines through shRNA-mediated EIF2S1 knockdown. The impact of EIF2S1 knockdown on the tumorigenesis of SK-N-SH cells was assessed in nude mice. <b>R"],"journal":["International journal of genomics"],"pagination":["6594426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11512646"],"repository":["biostudies-literature"],"pubmed_title":["EIF2S1 Silencing Impedes Neuroblastoma Development Through GPX4 Inactivation and Ferroptosis Induction."],"pmcid":["PMC11512646"],"pubmed_authors":["Liang S","Yuan T","Liu J","Li Z","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"EIF2S1 Silencing Impedes Neuroblastoma Development Through GPX4 Inactivation and Ferroptosis Induction.","description":"<b>Background:</b> Neuroblastoma (NB) is one of the most devastating malignancies in children, accounting for a high mortality rate due to limited treatment options. This study is aimed at elucidating the role of the ferroptosis-related EIF2S1 gene in NB pathogenesis and exploring its potential as a therapeutic target. <b>Methods:</b> We conducted comprehensive bioinformatics analyses utilizing the FerrDb database and NB-related transcriptomics data to investigate the role of EIF2S1 in NB. Changes in EIF2S1 expression were subsequently validated in NB tissues and cell lines. Loss-of-function experiments were performed in SK-N-SH and IMR-32 cell lines through shRNA-mediated EIF2S1 knockdown. The impact of EIF2S1 knockdown on the tumorigenesis of SK-N-SH cells was assessed in nude mice. <b>R","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T18:38:55.622Z","creation":"2025-04-06T14:21:59.141Z"},"accession":"S-EPMC11512646","cross_references":{"pubmed":["39465005"],"doi":["10.1155/2024/6594426"]}}