biostudies-literatureUnknown15Ferreira IA<h4>Introduction</h4>Despite being a bacterial pathogen with devastating consequences, <i>Tenacibaculum maritimum</i>'s pathogenesis is not fully understood. The aim of the present study was to elucidate if different inoculation routes (intraperitoneal - i.p - injection and bath challenge - known to induce mortality) can induce tenacibaculosis (i.e., using the same <i>T. maritimum</i> inoculum), as well as evaluate the short-term immune response of European sea bass (<i>D. labrax</i>). Additionally, the host response against i.p. injection of extracellular products (ECPs) was also studied.<h4>Methods</h4>Fish were i.p. challenged with 5.5 × 10⁵ CFU mL^-1 of <i>T. maritimum</i> cells with or without ECPs (BECPs and BWO, respectively), ECPs alone or marine broth (mock). Frontiers in immunology1478241https://www.ebi.ac.uk/biostudies/studies/S-EPMC11513285biostudies-literature<i>Tenacibaculum maritimum</i> can boost inflammation in <i>Dicentrarchus labrax</i> upon peritoneal injection but cannot trigger tenacibaculosis disease.PMC11513285Teixeira CFerreira IASantos PCostas Bdo Vale AMoxo JSfalse<i>Tenacibaculum maritimum</i> can boost inflammation in <i>Dicentrarchus labrax</i> upon peritoneal injection but cannot trigger tenacibaculosis disease.<h4>Introduction</h4>Despite being a bacterial pathogen with devastating consequences, <i>Tenacibaculum maritimum</i>'s pathogenesis is not fully understood. The aim of the present study was to elucidate if different inoculation routes (intraperitoneal - i.p - injection and bath challenge - known to induce mortality) can induce tenacibaculosis (i.e., using the same <i>T. maritimum</i> inoculum), as well as evaluate the short-term immune response of European sea bass (<i>D. labrax</i>). Additionally, the host response against i.p. injection of extracellular products (ECPs) was also studied.<h4>Methods</h4>Fish were i.p. challenged with 5.5 × 10⁵ CFU mL^-1 of <i>T. maritimum</i> cells with or without ECPs (BECPs and BWO, respectively), ECPs alone or marine broth (mock). 2024-01-01T00:00:00Z20242026-07-15T14:48:05.863Z2025-04-06T14:25:10.467ZS-EPMC115132853946972010.3389/fimmu.2024.1478241