{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(10)"],"submitter":["Wang Y"],"pubmed_abstract":["This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression. Two brain-dead patients undergo single kidney xenotransplantation, with kidneys donated by minipigs genetically modified to include triple-gene knockouts (GGTA1, β4GalNT2, CMAH) and human gene transfers (hCD55 or hCD55/hTBM). Renal xenograft functions are fully restored; however, immunosuppression without CD40-CD154 pathway blockade is ineffective in preventing acute rejection by day 12. This rejection manifests as both T cell-mediated rejection and antibody-mediated rejection (AMR), confirmed by natural killer (NK) cell and macrophage infiltration in sequential xenograft biopsies. Despite donor pigs being p"],"journal":["Cell reports. Medicine"],"pagination":["101744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11513830"],"repository":["biostudies-literature"],"pubmed_title":["Pig-to-human kidney xenotransplants using genetically modified minipigs."],"pmcid":["PMC11513830"],"pubmed_authors":["Liu L","Zhang K","Jiang H","Wen Q","Zhang M","Gan H","Pei H","Wang H","Wang J","Yu H","Wang M","Guo H","Chen ZK","Li B","Wang Y","Song Z","Yu Y","Xu L","You Y","Li D","Zhou S","Yang M","Chen G","He S","Pan D","Li T","Feng H","Du J"],"additional_accession":[]},"is_claimable":false,"name":"Pig-to-human kidney xenotransplants using genetically modified minipigs.","description":"This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression. Two brain-dead patients undergo single kidney xenotransplantation, with kidneys donated by minipigs genetically modified to include triple-gene knockouts (GGTA1, β4GalNT2, CMAH) and human gene transfers (hCD55 or hCD55/hTBM). Renal xenograft functions are fully restored; however, immunosuppression without CD40-CD154 pathway blockade is ineffective in preventing acute rejection by day 12. This rejection manifests as both T cell-mediated rejection and antibody-mediated rejection (AMR), confirmed by natural killer (NK) cell and macrophage infiltration in sequential xenograft biopsies. Despite donor pigs being p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T14:46:13.531Z","creation":"2026-07-06T03:08:41.864Z"},"accession":"S-EPMC11513830","cross_references":{"pubmed":["39317190"],"doi":["10.1016/j.xcrm.2024.101744"]}}