{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang M"],"funding":["Project of Jiangsu Province Traditional Chinese Medicine Science and Technology Development Program","Jiangsu Provincial Natural Science Foundation of Higher Education","the National Key Research and Development Program of China","the key project of the Grants from the National Key R&D Program of China","National Natural Science Foundation of China","the key project of the Grants from the National Key R&D Program of China"],"pagination":["149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11514841"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
Shen-Bai-Jie-Du decoction (SBJDD), a traditional Chinese herb formula developed based on evidence-based medicine, is efficacy to reduce the recurrence and carcinogenesis of colorectal adenoma. However, the mechanism of SBJDD to treat colorectal adenoma remains unclear. The present study aims to investigate the efficacy and mechanism of SBJDD on colorectal adenoma carcinogenesis from the aspects of regulating gut microbiota and short-chain fatty acids (SCFAs).Methods
Twenty-one patients diagnosed with colorectal adenoma were recruited in the study and required to take SBJDD for four consecutive weeks. Analysis of gut microbiota was conducted using 16S rRNA gene amplicon sequencing, while levels of SCFAs in fecal and serum samples were determined through HPLC-MS/MS"],"journal":["Chinese medicine"],"pubmed_title":["Shen-Bai-Jie-Du decoction suppresses the progression of colorectal adenoma to carcinoma through regulating gut microbiota and short-chain fatty acids."],"pmcid":["PMC11514841"],"funding_grant_id":["No. MS2022001","22KJB310003","81930117","2017YFC1700602","2022YFC3500202","2022YFC3500200","82405183"],"pubmed_authors":["Shen M","Tao L","Tan J","Huang M","Fan M","Xu C","Ni M","Li L","Lai Y","Yu C","Zhang Y","Tao Y","Sun D","Cheng H","Shen W"],"additional_accession":[]},"is_claimable":false,"name":"Shen-Bai-Jie-Du decoction suppresses the progression of colorectal adenoma to carcinoma through regulating gut microbiota and short-chain fatty acids.","description":"Background
Shen-Bai-Jie-Du decoction (SBJDD), a traditional Chinese herb formula developed based on evidence-based medicine, is efficacy to reduce the recurrence and carcinogenesis of colorectal adenoma. However, the mechanism of SBJDD to treat colorectal adenoma remains unclear. The present study aims to investigate the efficacy and mechanism of SBJDD on colorectal adenoma carcinogenesis from the aspects of regulating gut microbiota and short-chain fatty acids (SCFAs).Methods
Twenty-one patients diagnosed with colorectal adenoma were recruited in the study and required to take SBJDD for four consecutive weeks. Analysis of gut microbiota was conducted using 16S rRNA gene amplicon sequencing, while levels of SCFAs in fecal and serum samples were determined through HPLC-MS/MS","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T17:40:35.081Z","creation":"2026-07-07T03:10:51.045Z"},"accession":"S-EPMC11514841","cross_references":{"pubmed":["39465423"],"doi":["10.1186/s13020-024-01019-4"]}}