{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mogollon Garcia HD"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11514973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(1)"],"pubmed_abstract":["<h4>Background</h4>There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory changes. Molecular evaluations of ovarian follicular cells during follicular development in cattle, especially serial transcriptomic analyses across key growth phases, have not been reported. This study aims to address this gap by analyzing gene expression using RNA-seq in granulosa and antral cells recovered from ovarian follicular fluid during critical phases of ovarian follicular development in Holstein cows.<h4>Results</h4>Integrated analysis of gene ontology (GO), gene set enrichment (GSEA), protein-protein interaction (PPI), and gene topology identified that "],"journal":["Biological research"],"pubmed_title":["Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development."],"pmcid":["PMC11514973"],"funding_grant_id":["2012/18297-7","2011/20449-7","190043/2017-2"],"pubmed_authors":["de Andrade Ferrazza R","de Athayde FF","Sartori R","Ochoa JC","Mogollon Garcia HD","Ferreira JCP","Wiltbank M","Vidigal PMP","Kastelic JP"],"additional_accession":[]},"is_claimable":false,"name":"Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development.","description":"<h4>Background</h4>There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory changes. Molecular evaluations of ovarian follicular cells during follicular development in cattle, especially serial transcriptomic analyses across key growth phases, have not been reported. This study aims to address this gap by analyzing gene expression using RNA-seq in granulosa and antral cells recovered from ovarian follicular fluid during critical phases of ovarian follicular development in Holstein cows.<h4>Results</h4>Integrated analysis of gene ontology (GO), gene set enrichment (GSEA), protein-protein interaction (PPI), and gene topology identified that ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-06T03:13:04.28Z","creation":"2026-07-06T03:08:59.867Z"},"accession":"S-EPMC11514973","cross_references":{"pubmed":["39468655"],"doi":["10.1186/s40659-024-00558-2"]}}