{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Elnawam H"],"funding":["Alexandria University"],"pubmed_abstract":["<h4>Background</h4>The use of biological scaffolds in regenerative endodontics has gained much attention in recent years. The search for a new biomimetic scaffold that contains tissue-specific cell homing factors could lead to more predictable tissue regeneration. The aim of this study was to prepare and characterize decellularized bovine dental pulp-derived extracellular matrix (P-ECM) hydrogels for regenerative endodontic applications.<h4>Methods</h4>Freshly extracted bovine molar teeth were collected. Bovine dental pulp tissues were harvested, and stored at -40º C. For decellularization, a 5-day protocol was implemented incorporating trypsin/EDTA, deionized water and DNase treatment. Decellularization was evaluated by DNA quantification and histological examination to assess collagen an"],"journal":["BMC oral health"],"pagination":["1281"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11515367"],"repository":["biostudies-literature"],"pubmed_title":["Preparation and characterization of bovine dental pulp-derived extracellular matrix hydrogel for regenerative endodontic applications: an in vitro study."],"pmcid":["PMC11515367"],"pubmed_authors":["Thabet A","Abdallah A","Mobarak A","Elbackly R","Elnawam H"],"additional_accession":[]},"is_claimable":false,"name":"Preparation and characterization of bovine dental pulp-derived extracellular matrix hydrogel for regenerative endodontic applications: an in vitro study.","description":"<h4>Background</h4>The use of biological scaffolds in regenerative endodontics has gained much attention in recent years. The search for a new biomimetic scaffold that contains tissue-specific cell homing factors could lead to more predictable tissue regeneration. The aim of this study was to prepare and characterize decellularized bovine dental pulp-derived extracellular matrix (P-ECM) hydrogels for regenerative endodontic applications.<h4>Methods</h4>Freshly extracted bovine molar teeth were collected. Bovine dental pulp tissues were harvested, and stored at -40º C. For decellularization, a 5-day protocol was implemented incorporating trypsin/EDTA, deionized water and DNase treatment. Decellularization was evaluated by DNA quantification and histological examination to assess collagen an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T17:45:16.776Z","creation":"2026-07-07T03:11:00.004Z"},"accession":"S-EPMC11515367","cross_references":{"pubmed":["39448989"],"doi":["10.1186/s12903-024-05004-z"]}}