{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Meisinger C"],"funding":["Universitätsklinikum Augsburg"],"pubmed_abstract":["<h4>Background</h4>There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-specific cancers. However, the study results are very heterogeneous.<h4>Methods</h4>Based on up to 375,814 European women, we performed an iterative two-sample Mendelian randomization to assess causal effects of the occurrence of the inflammatory arthritis on the risk of female-specific cancer in form of breast, endometrial, and ovarian cancer sites as well as their subtypes. Evidence was strengthened by using similar exposures for plausibility or by replication with a subsequent meta-analysis. P-values were Bonferroni adjusted.<h4>Results</h4>Genetic liability to AS"],"journal":["Journal of translational medicine"],"pagination":["962"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11515448"],"repository":["biostudies-literature"],"pubmed_title":["Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers."],"pmcid":["PMC11515448"],"pubmed_authors":["Fischer S","Meisinger C","O'Mara T","Freuer D"],"additional_accession":[]},"is_claimable":false,"name":"Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers.","description":"<h4>Background</h4>There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-specific cancers. However, the study results are very heterogeneous.<h4>Methods</h4>Based on up to 375,814 European women, we performed an iterative two-sample Mendelian randomization to assess causal effects of the occurrence of the inflammatory arthritis on the risk of female-specific cancer in form of breast, endometrial, and ovarian cancer sites as well as their subtypes. Evidence was strengthened by using similar exposures for plausibility or by replication with a subsequent meta-analysis. P-values were Bonferroni adjusted.<h4>Results</h4>Genetic liability to AS","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T17:42:12.163Z","creation":"2026-07-07T03:10:44.259Z"},"accession":"S-EPMC11515448","cross_references":{"pubmed":["39449068"],"doi":["10.1186/s12967-024-05765-9"]}}