biostudies-literatureUnknown22(1)Meisinger CUniversitätsklinikum Augsburg<h4>Background</h4>There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-specific cancers. However, the study results are very heterogeneous.<h4>Methods</h4>Based on up to 375,814 European women, we performed an iterative two-sample Mendelian randomization to assess causal effects of the occurrence of the inflammatory arthritis on the risk of female-specific cancer in form of breast, endometrial, and ovarian cancer sites as well as their subtypes. Evidence was strengthened by using similar exposures for plausibility or by replication with a subsequent meta-analysis. P-values were Bonferroni adjusted.<h4>Results</h4>Genetic liability to ASJournal of translational medicine962https://www.ebi.ac.uk/biostudies/studies/S-EPMC11515448biostudies-literatureTwo-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers.PMC11515448Fischer SMeisinger CO'Mara TFreuer DfalseTwo-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers.<h4>Background</h4>There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-specific cancers. However, the study results are very heterogeneous.<h4>Methods</h4>Based on up to 375,814 European women, we performed an iterative two-sample Mendelian randomization to assess causal effects of the occurrence of the inflammatory arthritis on the risk of female-specific cancer in form of breast, endometrial, and ovarian cancer sites as well as their subtypes. Evidence was strengthened by using similar exposures for plausibility or by replication with a subsequent meta-analysis. P-values were Bonferroni adjusted.<h4>Results</h4>Genetic liability to AS2024-01-01T00:00:00Z2024 Oct2026-07-15T17:42:12.163Z2026-07-07T03:10:44.259ZS-EPMC115154483944906810.1186/s12967-024-05765-9