biostudies-literatureYang LProvincial Key Research and Development Program of Heilongjiang ProvinceHaiyan Fund of Harbin Medical University Cancer Hospital1316https://www.ebi.ac.uk/biostudies/studies/S-EPMC11515836biostudies-literatureUnknown24(1)<h4>Background</h4>Sentinel lymph node (SLN) biopsy (SLNB) is considered the gold standard for detecting SLN metastases in patients with invasive ductal breast cancer (IDC). However, SLNB is invasive and associated with several complications. Thus, this study aimed to evaluate the diagnostic performance of a non-invasive radiomics analysis utilizing 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) for assessing SLN metastasis in IDC patients.<h4>Methods</h4>This retrospective study included 132 patients with biopsy-confirmed IDC, who underwent ¹⁸F-FDG PET/CT scans prior to mastectomy or breast-conserving surgery with SLNB. Tumor resection or SLNB was conducted within one-week post-scan. Clinical data and metaBMC cancerCan we skip invasive biopsy of sentinel lymph nodes? A preliminary investigation to predict sentinel lymph node status using PET/CT-based radiomics.PMC11515836JJMS-2023-05GA21C001Ding HYang LXu SGao XWang KXu YfalseCan we skip invasive biopsy of sentinel lymph nodes? A preliminary investigation to predict sentinel lymph node status using PET/CT-based radiomics.<h4>Background</h4>Sentinel lymph node (SLN) biopsy (SLNB) is considered the gold standard for detecting SLN metastases in patients with invasive ductal breast cancer (IDC). However, SLNB is invasive and associated with several complications. Thus, this study aimed to evaluate the diagnostic performance of a non-invasive radiomics analysis utilizing 2-deoxy-2-[¹⁸F]fluoro-d-glucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) for assessing SLN metastasis in IDC patients.<h4>Methods</h4>This retrospective study included 132 patients with biopsy-confirmed IDC, who underwent ¹⁸F-FDG PET/CT scans prior to mastectomy or breast-conserving surgery with SLNB. Tumor resection or SLNB was conducted within one-week post-scan. Clinical data and meta2024-01-01T00:00:00Z2024 Oct2026-07-15T17:45:25.599Z2026-07-07T03:11:03.699ZS-EPMC115158363945590710.1186/s12885-024-13031-w