{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dasinger JH"],"funding":["NHLBI NIH HHS"],"pagination":["2357-2367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11517830"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(11)"],"pubmed_abstract":["<h4>Background</h4>Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS<sup>CD247-/-</sup> (Dahl SS CD247 knockout rat; lacking T cells), and SS<sup>p67phox-/-</sup> (Dahl SS p67<sup>phox</sup> [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.<h4>Methods</h4>We assessed blood pressure and renal damage phenotypes in SS, SS<sup>CD247-/-</sup>, and SS<sup>p67phox-/-</sup> rats during primigravida and multigravida states. To investiga"],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pubmed_title":["Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats."],"pmcid":["PMC11517830"],"funding_grant_id":["R00 HL157549","R01 HL161231","R01 HL166458","K99 HL157549","F32 HL143832"],"pubmed_authors":["Baldwin KE","Fehrenbach DJ","Burns-Ray EC","Cherian-Shaw M","Dasinger JH","Walton SD","Mattson DL","Abais-Battad JM"],"additional_accession":[]},"is_claimable":false,"name":"Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.","description":"<h4>Background</h4>Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS<sup>CD247-/-</sup> (Dahl SS CD247 knockout rat; lacking T cells), and SS<sup>p67phox-/-</sup> (Dahl SS p67<sup>phox</sup> [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.<h4>Methods</h4>We assessed blood pressure and renal damage phenotypes in SS, SS<sup>CD247-/-</sup>, and SS<sup>p67phox-/-</sup> rats during primigravida and multigravida states. To investiga","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T09:14:52.178Z","creation":"2026-05-15T03:11:51.34Z"},"accession":"S-EPMC11517830","cross_references":{"pubmed":["39301728"],"doi":["10.1161/HYPERTENSIONAHA.124.23303","10.1161/hypertensionaha.124.23303"]}}