biostudies-literatureDasinger JHNHLBI NIH HHS2357-2367https://www.ebi.ac.uk/biostudies/studies/S-EPMC11517830biostudies-literatureUnknown81(11)<h4>Background</h4>Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS^CD247-/- (Dahl SS CD247 knockout rat; lacking T cells), and SS^p67phox-/- (Dahl SS p67^phox [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.<h4>Methods</h4>We assessed blood pressure and renal damage phenotypes in SS, SS^CD247-/-, and SS^p67phox-/- rats during primigravida and multigravida states. To investigaHypertension (Dallas, Tex. : 1979)Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.PMC11517830R00 HL157549R01 HL161231R01 HL166458K99 HL157549F32 HL143832Baldwin KEFehrenbach DJBurns-Ray ECCherian-Shaw MDasinger JHWalton SDMattson DLAbais-Battad JMfalseIntact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.<h4>Background</h4>Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS^CD247-/- (Dahl SS CD247 knockout rat; lacking T cells), and SS^p67phox-/- (Dahl SS p67^phox [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.<h4>Methods</h4>We assessed blood pressure and renal damage phenotypes in SS, SS^CD247-/-, and SS^p67phox-/- rats during primigravida and multigravida states. To investiga2024-01-01T00:00:00Z2024 Nov2026-06-05T09:14:52.178Z2026-05-15T03:11:51.34ZS-EPMC115178303930172810.1161/HYPERTENSIONAHA.124.2330310.1161/hypertensionaha.124.23303