biostudies-literatureFarland LVNICHD NIH HHSNHLBI NIH HHSNCI NIH HHS952-958https://www.ebi.ac.uk/biostudies/studies/S-EPMC11518641biostudies-literatureUnknown31(11)<h4>Objectives</h4>To better understand whether history of infertility is associated with anti-Müllerian hormone (AMH) levels later in life, outside of reproduction.<h4>Methods</h4>Among 1,758 premenopausal women in the Nurses' Health Study II with measured AMH, we used multivariable generalized linear models to compare log-transformed plasma AMH for women with a history of infertility compared with fertile women. We investigated AMH levels by cause of infertility and effect modification by menstrual cycle regularity. Lastly, we investigated AMH levels by history of primary and secondary infertility and age at reported infertility.<h4>Results</h4>Mean age at blood collection was 40 years. We observed no association between overall history of infertility and AMH levels (% difference AMH: -8Menopause (New York, N.Y.)History of infertility and anti-Mullerian hormone levels among participants in the Nurses' Health Study II.PMC11518641R21 HD099623U01 HL145386U01 CA176726R01 HD078517R01 HD096033Eliassen AHMissmer SARich-Edwards JWGaskins AJFarland LVChavarro JEWang SDegnan WJBertone-Johnson ERfalseHistory of infertility and anti-Mullerian hormone levels among participants in the Nurses' Health Study II.<h4>Objectives</h4>To better understand whether history of infertility is associated with anti-Müllerian hormone (AMH) levels later in life, outside of reproduction.<h4>Methods</h4>Among 1,758 premenopausal women in the Nurses' Health Study II with measured AMH, we used multivariable generalized linear models to compare log-transformed plasma AMH for women with a history of infertility compared with fertile women. We investigated AMH levels by cause of infertility and effect modification by menstrual cycle regularity. Lastly, we investigated AMH levels by history of primary and secondary infertility and age at reported infertility.<h4>Results</h4>Mean age at blood collection was 40 years. We observed no association between overall history of infertility and AMH levels (% difference AMH: -82024-01-01T00:00:00Z2024 Nov2026-06-05T09:16:56.634Z2026-05-15T03:11:43.492ZS-EPMC115186413922641210.1097/gme.000000000000242410.1097/GME.0000000000002424