{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Granoski MB"],"funding":["NIDDK NIH HHS"],"pagination":["1427113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11518795"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<h4>Introduction</h4>The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis). Dysregulation of FOXC2 expression has also been found to promote defects in lymphatic remodeling and hyperplastic lymphedema-distichiasis (LD). Since chronic lymphedema is a forerunner of several malignancies and cancers have been known to arise from poorly healing chronic wounds (e.g., Marjolin ulcers), we examined the effect of Foxc2 dysfunction on skin wound healing.<h4>Methods</h4>We used our splinted excisional wounding model that mimics human-like wound healing on wildtype and Foxc2<sup>+/-</sup> mice (n = 4), which demonstrate incomplete l"],"journal":["Frontiers in physiology"],"pubmed_title":["Cancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation."],"pmcid":["PMC11518795"],"funding_grant_id":["R01 DK074095"],"pubmed_authors":["Kussie HC","Chen K","Gurtner GC","Yasmeh JP","Mora Pinos MG","Granoski MB","Hostler AC","McKenna E","Hahn WW","Fischer KS","Erickson RP","Sivaraj D","Quintero F","Alsharif AM","Witte MH"],"additional_accession":[]},"is_claimable":false,"name":"Cancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation.","description":"<h4>Introduction</h4>The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis). Dysregulation of FOXC2 expression has also been found to promote defects in lymphatic remodeling and hyperplastic lymphedema-distichiasis (LD). Since chronic lymphedema is a forerunner of several malignancies and cancers have been known to arise from poorly healing chronic wounds (e.g., Marjolin ulcers), we examined the effect of Foxc2 dysfunction on skin wound healing.<h4>Methods</h4>We used our splinted excisional wounding model that mimics human-like wound healing on wildtype and Foxc2<sup>+/-</sup> mice (n = 4), which demonstrate incomplete l","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-15T17:47:51.744Z","creation":"2025-04-04T01:58:38.473Z"},"accession":"S-EPMC11518795","cross_references":{"pubmed":["39473610"],"doi":["10.3389/fphys.2024.1427113"]}}