biostudies-literatureGranoski MBNIDDK NIH HHS1427113https://www.ebi.ac.uk/biostudies/studies/S-EPMC11518795biostudies-literatureUnknown15<h4>Introduction</h4>The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis). Dysregulation of FOXC2 expression has also been found to promote defects in lymphatic remodeling and hyperplastic lymphedema-distichiasis (LD). Since chronic lymphedema is a forerunner of several malignancies and cancers have been known to arise from poorly healing chronic wounds (e.g., Marjolin ulcers), we examined the effect of Foxc2 dysfunction on skin wound healing.<h4>Methods</h4>We used our splinted excisional wounding model that mimics human-like wound healing on wildtype and Foxc2^+/- mice (n = 4), which demonstrate incomplete lFrontiers in physiologyCancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation.PMC11518795R01 DK074095Kussie HCChen KGurtner GCYasmeh JPMora Pinos MGGranoski MBHostler ACMcKenna EHahn WWFischer KSErickson RPSivaraj DQuintero FAlsharif AMWitte MHfalseCancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation.<h4>Introduction</h4>The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis). Dysregulation of FOXC2 expression has also been found to promote defects in lymphatic remodeling and hyperplastic lymphedema-distichiasis (LD). Since chronic lymphedema is a forerunner of several malignancies and cancers have been known to arise from poorly healing chronic wounds (e.g., Marjolin ulcers), we examined the effect of Foxc2 dysfunction on skin wound healing.<h4>Methods</h4>We used our splinted excisional wounding model that mimics human-like wound healing on wildtype and Foxc2^+/- mice (n = 4), which demonstrate incomplete l2024-01-01T00:00:00Z20242026-07-15T17:47:51.744Z2025-04-04T01:58:38.473ZS-EPMC115187953947361010.3389/fphys.2024.1427113